肿瘤基因治疗相关的特异性启动子研究新进展  

The new progress of the specific promoter for cancer gene therapy

作　　者：李玮[1] 谭建[1] 

机构地区：[1]天津医科大学总医院核医学科,300052

出　　处：《国际放射医学核医学杂志》2014年第3期185-189,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81301244,81171372）;天津市应用基础及前沿技术研究计划项目（12JCZDJC26000）

摘　　要：肿瘤基因治疗是一种在基因水平上治疗肿瘤的方法，是现有治疗肿瘤的先进方法之一。但是，肿瘤基因治疗技术还存在很多未解决的问题，例如目的基因表达的靶向性问题等。现有研究证实，使用特异性启动子可以提高肿瘤基因治疗的靶向性。启动子是指能启动mRNA转录的一段特异性DNA序列，特异性启动子是指仅在特定组织或肿瘤中才会被激活的启动子。该文将就肿瘤基因治疗相关的特异性启动子的近期研究，按启动子的作用类型进行综述。Cancer gene therapy is a way to treat cancer at the gene level which is one of the effec-tive methods for cancer therapy. But, there are still some outstanding problems, for example, the targeting of gene expression. Recent researches confirm that the specific promoter can improve the targeting in gene therapy. The promoter is a region of DNA which can initiates transcription of a particular gene. The specif-ic promoter only can be activated in certain tissue or tumor. Based on the recent studies in this field, this article will introduce types and functions of specific promoters, which has been investigated in cancer gene therapy.

关 键 词：启动区(遗传学) 基因疗法 靶向疗法 

分 类 号：R730.5[医药卫生—肿瘤]