五羟色胺转运体启动子区基因多态性与强迫症状和认知功能的关联研究  

Association between the polymorphism of 5-HTTLPR gene and OCD symptoms,cognitive function

作　　者：刘恩益[1] 刘玉平[1] 文启琴[1] 苗国栋[1] 曾俏梅[1] 

机构地区：[1]广州市精神病医院临床心理科,510370

出　　处：《中华临床医师杂志（电子版）》2013年第7期84-86,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：广东省自然科学基金资助项目(6012929)

摘　　要：目的探讨五羟色胺转运体启动子区(5-HTTLPR)基因多态性与强迫症患者认知功能、强迫症状之间是否存在关联性。方法采用聚合酶链式反应(PCR)及扩增片段长度多态性技术检测104例强迫症患者的5-HTTLPR基因的多态性;采用威斯康星卡片分类测试(WCST)、连线试验A和B测评所有患者的执行功能、注意;耶鲁-布朗强迫量表(YBOCS)评估患者的强迫症状。结果不同基因型(S/S,S/L,L/L)组间强迫症患者的WCST测试、连线测试无显著性差异(P>0.05);并且三个基因型组间强迫症状总分、强迫思维和行为的差异也无统计学意义(P>0.05)。结论本研究的结果不支持5-HTTLPR基因多态性作为强迫症临床症状或认知功能损害的候选基因。Objective To explore the association between the polymorphism of serotonin transporter promoter region （5-HTTLPR） gene and cognitive function,OCD symptoms in obsessive-compulsive disorder;Methods The polymerase chain reaction （PCR）-amplified fragment length polymorphism technique was used to exam 5-HTTLPR gene polymorphism in 104 OCD patients ;Wisconsin card sorting test （WCST）,Trail making test A and B （TMT A and B） were used to test executive function,attention;Yale-Brown obsessive compulsive scale was employed to evaluate OCD symptoms.Results In this study,No significant difference of WSCT,TMT A and B （P ＞ 0.05） was found among S/S,S/L,L/L genotypic groups.There was no statistical difference （P ＞ 0.05） of OCD symptoms in the three groups either.Conclusion In according to the results of present study,there is no evidence shows that the polymorphism of 5-HTTLPR gene is related to OCD symptoms or cognitive function.

关 键 词：强迫症 认知功能 临床症状 五羟色胺转运体 

分 类 号：R749.7[医药卫生—神经病学与精神病学]