肠源性内毒素血症对阿尔茨海默病发病的影响  

Impact of intestinal endotoxemia on Alzheimer disease and its possible mechanisms

作　　者：吴凡[1] 韩柏[2,3] 韩德五[1] 刘克战[4] 赵楠[2] 邓福栋[2] 单希征[3] 

机构地区：[1]山西医科大学病理生理教研室,太原030001 [2]山西医科大学第一医院精神科 [3]中国武警总医院(北京)眩晕病研究所 [4]山西省儿童医院儿内科

出　　处：《中华临床医师杂志（电子版）》2013年第6期52-54,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：山西省科技攻关项目(2007031092-8);山西省回国留学人员科研资助项目(2007-13-89);中国武警总医院博士后基金(2010-42217);山西省留学回国人员科技活动择优资助(2013-68)

摘　　要：目的探讨肠源性内毒素血症对阿尔茨海默病(AD)患者的作用及其可能机制。方法通过神经心理学测验检测入组患者认知功能,分为AD组和健康对照者各40例,采用显色基质鲎试剂法检测脂多糖(LPS)水平,ELISA法检测TNF-α和Tau蛋白水平。结果 AD患者MMSE、ADAS-Cog分数与对照组比较,MMSE分数明显低于对照组(t=16.473,P<0.001),ADAS-Cog分数明显高于对照组(t=18.067,P<0.001);LPS、TNF-α及Tau蛋白水平明显高于对照组(t=5.317,P<0.001;t=5.014,P<0.001;t=17.393,P<0.001)。结论 AD患者存在肠源性内毒素血症,并可能在AD发病过程中发挥重要作用。Objective To study the effect of intestinal endotoxemia（IETM） on Alzheimer＇s disease （AD） and its possible mechanisms.Methods Through cognitive function in patients with neuropsychological testing into the test group,divided into the AD group and healthy controls 40 cases in each group.Lipopolysaccharides（LPS） level was detected by CE TAL;TNF-α and Tau protein levels were tested by ELISA.Results In patients with AD,MMSE scores were significantly lower than control group（t =16.473,P ＜ 0.001）,ADAS-Cog score were significantly higher than the control group（t =18.067,P ＜ 0.001） ;LPS,TNF-α and Tau protein levels were significantly higher than control group（t =5.317,P ＜ 0.001 ; t =0.001,P ＜ 0.001 ; t =0.001,P ＜ 0.001）.Conclusions Patients with AD accompanied with IETM.It may be play an important role in the course of AD.

关 键 词：内毒素血症 阿尔茨海默病 TAU蛋白质类 脂多糖类 肿瘤坏死因子Α 

分 类 号：R749.16[医药卫生—神经病学与精神病学]