食物不耐受与非酒精性脂肪肝的关系研究  

Study on the relationship of food intolerance and nonalcoholic fatty liver

作　　者：王仁萍[1] 赵新秀[2] 袁梅[1] 周静[1] 代玲玲[1] 

机构地区：[1]青岛大学医学院附属医院健康体检中心,山东省266003 [2]青岛大学医学院附属医院特需保健科

出　　处：《中华临床医师杂志（电子版）》2013年第12期89-92,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的通过检测14种食物成分的特异性IgG水平，研究食物不耐受与非酒精性脂肪肝、高脂血症的关系。方法选择2011～2013年青岛市1052名健康体检者，应用酶联免疫法（ELISA）检测血清14种食物特异性IgG抗体，采用SPSS 17.0软件对相关资料进行χ^2检验、非条件Logistic回归分析。结果（1）1052名受检人群中牛奶不耐受（χ^2=70.457， P＜0.05）、螃蟹不耐受（χ^2=49.040， P＜0.05）、海虾不耐受（χ^2=20.692，P＜0.05）与非酒精性脂肪肝有关；牛奶不耐受与高脂血症有关（χ^2=24.871，P＜0.05）。（2）分别以非酒精性脂肪肝、高脂血症为因变量，年龄、性别、体重指数（BMI）、海鲜和（或）非海鲜类食物不耐受为自变量进行多因素Logistic回归分析，结果显示非酒精性脂肪肝、高脂血症与海鲜、非海鲜类食物均不耐受组及海鲜类食物不耐受、非海鲜类食物耐受组比较，差异有统计学意义， OR 值（95％ CI）分别为1.361（1.018～2.057）、1.372（1.040～6.071）、16.976（2.519～125.634）、2.674（1.481～37.087）。结论牛奶、螃蟹、海虾不耐受以及BMI与非酒精性脂肪肝有关，其中牛奶不耐受与非酒精性脂肪肝、高血脂均有关，海产品中螃蟹、海虾不耐受与非酒精性脂肪肝有关；海鲜类食物不耐受较非海鲜类食物不耐受更易导致非酒精性脂肪肝、高脂血症。因此，建议据食物不耐受检测结果加强饮食管理，预防非酒精性脂肪肝、高脂血症的发病。Objective To investigate the association between food intolerance and nonalcoholic fatty liver , hyperuricemia .Methods A total of 1052 Qingdao residents were recruited in this study from 2011 to 2013 .ELISA was used to test specific allergic IgG antibodies .Chi-square test and Logistic regression were used for data analysis by SPSS 17.0 .Results （ 1 ） In the 1052 residents , there were significant difference between food intolerance and nonalcoholic fatty liver：milk intolerance and nonalcoholic fatty liver （χ^2=70.457,P〈0.05）,Crab intolerance and nonalcoholic fatty liver （χ^2=49.040 ,P〈0.05 ）;Prawns intolerance and nonalcoholic fatty liver （χ^2=20.692 , P〈0.05 ）;There was significant difference between food intolerance and hyperlipidemia ： milk intolerance and hyperlipidemia（χ^2=24.871,P〈0.05）;（2）In logistic regression analysis,there was significant difference between nonalcoholic fatty liver and sea food intolerance ,non sea food intolerance ,the odds ratio was 1.361（1.018-2.057）;Nonalcoholic fatty liver and sea food intolerance ,non sea food intolerance：1.372 （1.040-6.071 ）;Hyperlipidemia and sea food intolerance,non sea food tolerance：16.976（2.519-125.634）;Hyperlipidemia and sea food intolerance ,non sea food tolerance：2.674 （1.481-37.087）.Conclusion There is correlation between milk,crab,eggs,Prawns intolerance ,BMI and nonalcoholic fatty liver ,hyperuricemia;The risk of suffering nonalcoholic fatty liver is larger in sea food intolerance than non sea food;Sea food intolerance result in nonalcoholic fatty liver , hyperlipidemia more easily than non sea food .Therefore , food adjustment might be useful in the prevention and treatment of metabolic disease according to the test results the food intolerance .

关 键 词：脂肪肝 食物不耐受 非酒精性脂肪肝 高脂血症 相关性分析 

分 类 号：R575.5[医药卫生—消化系统]