不同压力智能型人工肛门封堵装置封堵效果试验  

Blocking Effect Test of Different Pressures of Intelligent Colostomy Closure Device

作　　者：谢朗[1] 黄宗海[1] 陈飞[1] 俞金龙[1] 崔春晖[1] 黎志超[1] 

机构地区：[1]南方医科大学珠江医院普通外科,广东广州510282

出　　处：《现代生物医学进展》2014年第12期2234-2238,共5页Progress in Modern Biomedicine

基　　金：广州市海珠区科技计划项目(2010-C-17)

摘　　要：目的:比较不同压力智能型人工肛门封堵装置的效果。方法:选用8-10月龄西藏小型猪进行动物试验。先进行结肠造口动物模型制备,再设计为3个不同气囊压力组分别接受试验。观察动物一般情况、造口泄露率、造口处肠壁粘膜组织中性粒细胞和淋巴细胞及肠管局部血流灌注量,并对应进行各影响因素的综合分析。结果:33.33 mmHg的压力组较之于其它两组,一般情况较差,体重下降明显(p=0.004);造口泄漏率最低,但造口处肠壁粘膜组织中性粒细胞和淋巴细胞显著上升(p=0.000);肠管局部血流灌注量显著下降(p=0.000),提示压力太大易致使造口处血运变差及并发感染。结论:压力过大时对周围组织及肠管压迫严重,容易引起缺血、坏死、感染等并发症。压力过小时又易发生泄漏,无法达到封堵目的。以气囊压力约18 mmHg较为适宜。Objective：To observe the effects of different pressure of intelligent colostomy closure device.Methods：To do animal experiments with 8-10 months old Tibet mini-pigs.First prepare with animal models with colostomy,and design of three different groups with balloon pressure to test,to observate the animals＇ general,stoma leakage rate,stoma neutrophils and lymphocytes and intestinal perfusion partial bowel mucosa and correspond to conduct a comprehensive analysis of each factor.Results：The general condition of the 33.33 mmHg pressure group were more poor than other two groups,their body weight decreased significantly（p=0.004）;Ostomy leakage rate was lowest,but stoma neutrophils and lymphocytes in intestinal mucosa increased significantly（p=0.000）;Partial intestinal perfusion decreased significantly（p=0.000）,too much pressure will cause to poor blood supplement in stoma and susceptible.Conclusion：If pressure is excessive,it will oppress on the surrounding tissue and intestinal severely,to cause ischemia,necrosis,infection and other complications.If pressure is too small,it will prone to leak,and it can not achieve the purpose of blocking.So the balloon pressure in 18mmHg is more appropriate.

关 键 词：智能型人工肛门封堵装置 动物试验 结肠造口模型 肠管局部血流灌注量 两因素重复测量分析 两因素裂区分析 

分 类 号：Q95-3[生物学—动物学] R735.37[医药卫生—肿瘤]