右美托咪定与咪达唑仑用于肠镜检查患者镇静效果比较  

The Comparison of Sedation with Dexmedetomidine and Midazolam Used for Enteroscopy

作　　者：李元曦 曲学华[2] 李洪颖[1] 罗振红[1] 丛珊[2] 刘冰[2] 崔晓光[1] 

机构地区：[1]哈尔滨医科大学附属第二医院麻醉科,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第四医院,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2014年第12期2293-2295,共3页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金重点项目(ZD201017)

摘　　要：目的:比较右美托咪定与咪达唑仑用于肠镜检查患者效果比较。方法:肠镜检查的患者60例,随机分为两组:D组静脉输注右美托咪定0.6μg/kg,M组静脉输注咪达唑仑0.08 mg/kg,均用生理盐水10 mL稀释,10 min输注完毕后进行肠镜检查。观察患者血流动力学指标及呼吸指标的变化,是否完成肠镜,患者的满意度以及检查过程中的不良反应。结果:右美托咪定组所有患者镇静满意,均能很好耐受肠镜检查,并且检查过程中MAP、HR和SpO2稳定(P>0.05)。咪达唑仑组镇静时有轻度呼吸抑制,肠镜检查过程中MAP和HR升高(P<0.05),插管耐受率低于右美托咪定组(P<0.05)。结论:右美托咪定用于肠镜镇静有效,无呼吸抑制,血流动力学稳定,是理想的辅助药。Objective：Dexmedetomidine compared with midazolam given for colonoscopy patient Comparison.Methods：60 patients with Colonoscopy were randomly divided into two groups.Group D was given dexmedetomi- dine with dose of 0.6 μg/kg,while group M received intravenous infusion of midazolam 0.08mg/kg,both were diluted with saline 10 mL.10min after infusion,patients were underbent colonoscopy.hemodynamic and respiratory indicators of change,whether complete colonoscopy,patient satisfaction,and adverse reactions during the inspection were observed.Results：dexmedetomidine sedation in all patients given group were well tolerated with colonoscopy process of MAP,HR and SpO2stable（P〉0.05）.Midazolam group had mild res- piratory depression and sedation,and MAP and HR during colonoscopy is below tolerance compared with dexmedetomidine group（P〈0.05）.Conclusion：Dexmedetomidine,with less respiratory depression and hemodynamic stability,is the ideal adjuvant drugs for colonoscopy sedation.

关 键 词：肠镜 右美托咪定 咪达唑仑 镇静效果 

分 类 号：R614[医药卫生—麻醉学]