小剂量奥美拉唑用于治疗功能性消化不良的效果分析  

Clinical Efficacy of Low-dosed Omeprazole on the Treatment of Functional Dyspepsia

作　　者：朱敏[1] 袁昌琼[1] 杨慧英[1] 腾菲[1] 郭晓东[2] 李明阳[3] 

机构地区：[1]解放军总医院南楼消化科,北京100853 [2]解放军第302医院,北京100039 [3]解放军总医院消化内镜诊疗科,北京100853

出　　处：《现代生物医学进展》2014年第13期2511-2513,共3页Progress in Modern Biomedicine

基　　金：解放军总医院临床科研扶持基金(2012FC-TSYS-3011);国家自然科学基金青年科学基金项目(30901795)

摘　　要：目的:分析小剂量奥美拉唑用于治疗功能性消化不良的临床效果。方法:选取我院2009年10月至2011年8月收治的260例功能性消化不良患者,随机分为观察组(148例)和对照组(112例)。观察组患者采取口服小剂量奥美拉唑进行治疗,对照组患者采取口服埃索美啦唑联合多潘立酮进行治疗。观察并比较两组患者的胃部烧灼感、餐后饱胀、上腹痛、嗳气等临床症状的改善情况。结果:经过两周的治疗,两组治疗患者的胃部烧灼感、上腹痛、嗳气及餐后饱胀等功能性消化不良病症的改善情况没有明显差异(P>0.05)。结论:小剂量奥美拉唑用于治疗功能性消化不良,其效果与埃索美拉唑联合多潘立酮药物的治疗效果相当,且患者治疗后的不良反应发生率低,可作为临床治疗功能性消化不良的有效药物。Objective： To analyze the clinical effects of low-dosed omeprazole on the treatment of functional dyspepsia. Methods： 260 patients who were treated with functional dyspepsia in our hospital from October 2009 to August 2011 were selected and randomly divided into the observation group（148 cases） and the control group（112 cases）. The patients in observation group were treated by low-dosed omeprazole, while patients in control group were treated by esomeprazole combined with domperidone. The clinical symptoms of patients＇ adverse reactions induced by functional dyspepsia which including the sense of stomach burned, epigastric pain, glutted and eructation were observed and compared between two groups. Results： After two-week＇ s treatment, there was no statistically significant difference between wo groups in terms of the above clinical symptoms of adverse reactions induced by functional dyspepsia（P 0.05）. Conclusions： The application of low-dosed omeprazole on the treatment of functional dyspepsia could be equal to the esomeprazole combined with domperidone for their clinical effects. What＇s more, the use of omeprazole has showed us a low incidence of adverse reactions so that it could be selected as an effective drug to treat the functional dyspepsia.

关 键 词：功能性消化不良 奥美拉唑 小剂量用药 治疗效果 

分 类 号：R57[医药卫生—消化系统]