PTEN基因和P53基因在子宫内膜癌中的表达及意义  

Expression and Clinical Significance of PTEN Gene and P53 Gene in Endometrial Carcinoma

作　　者：尹肖云[1] 乔丽雅[1] 王红英[1] 张秦[1] 杨夕粉[1] 王振国[1] 

机构地区：[1]解放军第309医院妇产科,北京100091

出　　处：《现代生物医学进展》2014年第14期2628-2631,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30872749)

摘　　要：目的:探讨PTEN基因和P53基因在子宫内膜癌中的表达及临床意义,为子宫内膜癌的治疗提供参考依据。方法:用免疫组化法检测50例子宫内膜癌患者PTEN基因缺失和P53基因突变情况,并分析两者与子宫内膜癌不同病理变化的相关性。结果:PTEN缺失24例,缺失率48.00%,进一步研究显示PTEN缺失与细胞分化程度和肌层浸润情况密切相关(P<0.05),P53突变32例,缺失率64.00%,并进一步研究显示P53突变与FIGO分期,细胞分化程度和肌层浸润情况密切相关(P<0.05)。结论:PTEN基因缺失和P53基因突变与子宫内膜癌发生和发展密切相关,以PTEN基因和P53基因为靶点的生物治疗在进展期内膜癌中的治疗价值值得进一步深入研究。Objective： To study the effect of deletion of PTEN Gene and mutation of P53 gene on endometrial carcinoma, provides the reference for the treatment of uterine endometrial carcinoma. Methods： Immunohistochemistry was used to deletion of PTEN Gene and mutation of P53 gene, and analyze both with endometrial cancer pathology. Results： Deletion of PTEN Gene in 24 cases, the loss rate of 48% Further study showed that the expression of deletion of PTEN gene significantly correlated with cell differentiation and myometrial invasion（P〈0.05）, mutation of P53 gene the mutation being64.00%, and Further study showed that the mutation of P53 gene significantly correlated with FIGO stage, cell differentiation and myometrial invasion situation（P〈0.05）. Conclusion： Deletion of PTEN gene and mutation of P53 gene, was associated with endometrial carcinoma development. The PTEN gene and P53 gene as the therapeutic value of target of biological treatment in the progression of endometrial carcinoma is worthy of further study.

关 键 词：PTEN P53 子宫内膜癌 

分 类 号：R737.33[医药卫生—肿瘤]