不同年龄乳腺癌基因分型的对比研究  

Comparative Study Of Genetic Typing In Breast Cancer With Different Ages

作　　者：晏昱婧 董鸿[1] 罗智勇[2] 夏耘[1] 汪洁[1] 吴亚群[1] 

机构地区：[1]华中科技大学附属同济医院甲状腺乳腺外科,武汉湖北430030 [2]华中科技大学附属同济医院甲状腺乳腺外,科武汉湖北430030

出　　处：《现代生物医学进展》2014年第14期2672-2674,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金面上项目(81172512)

摘　　要：目的:对不同年龄乳腺癌患者基因分型的分布特点进行分析,为乳腺癌的治疗和预后判断提供参考依据。方法:回顾性分析青年、中年、老年乳腺癌患者的临床资料,对其基因分型分布进行对比分析。结果:不同年龄(≤40岁、40岁-60岁、≥60岁)乳腺癌的基因分型分布比较有显著性差异,存在统计学意义(P<0.05),年轻乳腺癌患者中≤35岁与35-40岁患者的基因分型的分布也存在显著性差异(P<0.05)。结论:不同年龄乳腺癌人群的基因分型不同,需结合其他临床和病理指标综合评估患者病情及预后;老年乳腺癌患者基因分型的分布并不乐观,需强调早期诊断和治疗。Objective： To analyze the genetic typing in breast cancer with different ages and guide the treatment and prognosis of breast cancer. Methods： The clinical data of young, middle-aged, old patients with breast cancer were analyzed retrospectively. Results： The genetic typing distribution of breast cancer with different ages had statistical difference（P〈0.05）, and the genetic typing distribution in young breast cancer patients（≤35years） with the patients in 35-40years were also significantly different（P〈0.05）. Conclusions： The genetic typing distribution of breast cancer with different ages were different, comprehensive evaluation of patients＇ condition and prognosis should be combined with other clinical and pathological information. The genetic typing in elderly patients with breast cacner was not optimistic, which was needed to be emphasized on the early diagnosis and treatment.

关 键 词：乳腺癌 基因分型 年龄 

分 类 号：R737.9[医药卫生—肿瘤]