糖尿病视网膜病变患者多次住院的影响因素分析  

Analysis of the Risk Factors of Repeated Hospitalization of Patients with Diabetic Retinopathy

作　　者：秦丽敏[1] 刘铁城[1] 戴英丽 余继峰 

机构地区：[1]解放军总医院眼科,北京100853 [2]沈阳市第二中医院眼科,沈阳辽宁110101 [3]北京儿童医院眼科,北京100000

出　　处：《现代生物医学进展》2014年第14期2675-2678,共4页Progress in Modern Biomedicine

基　　金：解放军总医院院扶持基金(2012FC-CXYY-1005)

摘　　要：目的：探讨糖尿病视网膜病变（DR）患者多次住院（住院次数≥2）的影响因素。方法：以2型糖尿病（DM）并因糖尿病视网膜病变（DR）相关并发症多次住院（住院次数≥2）的患者为实验组,对照组为非糖尿病多次因眼科相关疾病住院（住院次数≥2）患者。比较两组患者在第二次住院时的发病年龄、空腹血糖（fasting blood glucose,GLU）、糖化血清蛋白（glycated serum protrin,GSP）、丙氨酸氨基转移酶（Alanine aminotransferase,ALT）、天冬氨酸氨基转移酶（aspartate aminotransferase,AST）、肌酐（creatinine,Cr）、尿素（urea）、总胆汁酸（total bile acid,TBA）、血清尿酸（uric acid,UA）、甘油三酯（triglycetide,TG）、胆固醇（cholesterol,Ch）、体质指数（body mass index,BMI）等。结果：单因素分析结果显示入院时血糖、糖化血清蛋白、血清尿酸、甘油三酯、胆固醇与DR患者多次住院（住院次数≥2）显著相关（P均≤0.01）。多因素Logistic回归分析显示：空腹血糖（P=0.038;95%CI：1.101-26.325）、糖化血清蛋白（P=0.003;95%CI：1.017-1.082）、尿酸（P=0.167;95%CI：0.994-1.032）、甘油三脂（P=0.023;95%CI：1.774-2228.179）、胆固醇（P=0.029;95%CI：1.317-166.317）水平是DR患者多次住院（住院次数≥2）的独立危险因素。结论：空腹血糖、糖化血清蛋白、尿酸、甘油三脂和胆固醇是DR患者多次住院（住院次数≥2）的独立危险因素。Objective： To investigate the risk factors of repeated hospitalization of patients（number of hospitalizations≥2） with diabetic retinopathy. Methods： The experimental group were diagnosed as type 2 diabetes mellitus（DM） patients, which hospitalized several times（number of hospitalizations≥2） due to diabetic retinopathy（DR）-relatde complicatons. The control group were non-diabetic retinopathy patients with ophthalmic diseases, which hospitalized several times（number of hospitalizations≥2）. The clinical parameters and biochemical indicators were compared between two groups, including age of onset,fasting blood glucose（GLU）, glycated serum protrin（GSP）, Alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, creatinine（Cr）, urea, total bile acid（TBA）, uric acid（UA）, triglycetide（TG）, cholesterol（Ch）, body mass index（BMI）. Results： Univariate analysis, showed that GLU, GSP, UA, TG and Ch were significantly associated with DR patients（number of hospitalizations≥2）（P≤0.001）. Logistic regression analysis showed that GLU（P=0.038; 95% CI： 1.101-26.325）, GSP（P=0.003; 95% CI： 1.017-1.082）, UA（P=0.167; 95% CIL 0.994-1.032）, TG（P=0.023; 95% CI： 1.774-2228.179） and Ch（P=0.029; 95%CI： 1.317-166.317） were independent risk factors of DR patients（number of hospitalizations ≥ 2）. Conclusion： GLU, GSP UA,TG and Ch level were independent risk factors for DR patients（number of hospitalizations ≥2）.

关 键 词：糖尿病视网膜病变 危险因素 多次住院 

分 类 号：R774.1[医药卫生—眼科]