改良根治性与根治性子宫切除在控制Ⅰ期子宫内膜样腺癌复发中的临床价值  

Clinical Value of Modified Radical and Radical Hysterectomy in Controlling the Recurrence of Endometrioid Adenocarcinoma at StageⅠ

作　　者：魏永芹[1] 孟元光[1] 郭晓东[2] 张云[1] 汪淑娟[1] 

机构地区：[1]解放军总医院妇产科,北京100853 [2]解放军第302医院,北京100039

出　　处：《现代生物医学进展》2014年第14期2690-2692,共3页Progress in Modern Biomedicine

摘　　要：目的:探究改良根治性与根治性子宫切除治疗Ⅰ期子宫内膜样腺癌的临床价值,为临床Ⅰ期子宫内膜样腺癌的治疗提供指导和借鉴。方法:选取我院2007年1月至2008年12月期间收治的Ⅰ期子宫内膜样腺癌患者为研究对象,共计91例,根据患者临床治疗方法不同分成观察组(n=47)和对照组(n=44),观察组患者采用改良根治性与根治性子宫切除术,对照组采用改良根治性与根治性子宫切除+盆腔淋巴结清扫术,分析比较两组患者的手术时间、术中出血量、并发症和5年生存率等。结果:在手术时间、手术出血量和住院时间上,组间比较,观察组患者的指标水平均显著优于对照组患者,且差异具有统计学意义(P<0.05);在并发症发生率上,组间比较,观察组患者并发症发生率显著低于对照组患者的并发症发生率,且差异具有统计学意义(P<0.05);5年生存率和局部复发率,组间比较差异无统计学意义(P>0.05)。结论:采用改良根治性与根治性子宫切除术治疗Ⅰ期子宫内膜样腺癌具有较好的临床效果,可以有效的控制患者的复发率,淋巴结清扫术并不能显著改善复发率。Objective： To explore the clinical value of modified radical and radical hysterectomy in endometrioid adenocarcinoma at stage I, and provide guide and reference for the treatment of endometrioid adenocarcinoma at stage I. Methods： 91 patients with the endometrioid adenocarcinoma at stage I in our hospital from January 2007 to December 2008 were enrolled and divided into observation group（n=47） and control group（n=44） according to the clinical treatment methods. The observation group was treated with modified radical and radical hysterectomy, and the control group was treated with modified radical, radical resection and pelvic lymphadenectomy of uterus. Results： The operation time, intraoperative blood loss and hospitalization time of observation group were all significantly better than those of control group, and the differences were statistically significant（P〈0.05）; the complications rate of observation group was significantly lower than that of control group, and the differences were statistically significant（P〈0.05）; there was no statistical differences between the five-year survival rate and local recurrence rate of two groups（P〈0.05）. Conclusions： Modified radical and radical hysterectomy could achieve good clinical effect in treating endometrioid adenocarcinoma at stage I and can effectively control the recurrence rate. The lymphadenectomy can＇t significantly improve the recurrence rate.

关 键 词：根治性子宫切除 Ⅰ期子宫内膜样腺癌 复发率 

分 类 号：R737.33[医药卫生—肿瘤] R713[医药卫生—临床医学]