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作 者:章群[1] 汪灏[1] 沈洁[1] 胡静[1] 禹立霞[1] 管文贤[1] 钱晓萍[1] 刘宝瑞[1]
机构地区:[1]南京大学医学院附属鼓楼医院肿瘤中心,江苏省210008
出 处:《江苏医药》2014年第9期1027-1029,共3页Jiangsu Medical Journal
基 金:国家自然科学基金(81172094);江苏省自然科学基金(BK2011095)
摘 要:目的探讨结直肠癌组织乳腺癌易感基因1(BRCA1)表达与多西紫杉醇、奥沙利铂体外敏感性的关系。方法实时荧光定量PCR检测50例病理确诊的人结直肠癌组织中BRCA1mRNA表达。采用组织培养药敏法评估多西紫杉醇和奥沙利铂两种药物的体外敏感性。结果多西紫杉醇和奥沙利铂平均抑制率分别为34.91%和43.75%。25例多西紫杉醇敏感组织和25例多西紫杉醇耐药组织中BRCA1mRNA相对表达量相仿(6.19vs.4.27)(P>0.05)。25例奥沙利铂敏感组织BRCA1mRNA相对表达量低于25例奥沙利铂耐药组织(3.86vs.6.59)(P<0.05)。结论结直肠癌组织对奥沙利铂的敏感性与BRCA1mRNA表达水平呈负相关。Objective To investigate the relationship of breast cancer susceptibility gene 1 (BRCA1) mRNA expression in colorectal cancer and in vitro chemosensitivity of cancer cells to docetaxel and oxaliplatiin. Methods The expression of BRCA1 mRNA was detected by quantitative RT-PCR in 50 samples of human colorectal cancer. The chemosensitivity to docetaxel and oxaliplatin was determined by histoculture drug response assay. Results The inhibition rates of docetaxel and oxaliplatin were 34.91% and 43.75%, respectively. BRCA1 mRNA expression in tissues sensitive to docetaxel(25 samples) was similar to that in those resistant to docetaxel (25 samples) (6.19 vs. 4.27) (P〉0.05). BRCA1 mRNA expression was lower in coloreetal cancer tissues sensitive to oxaliplatin (25 samples) than that in those resistant to oxaliplatin (25 samples) (3.86 vs. 6.59) (P〈0.05). Conclusion There is a negative correlation between BRCA1 mRNA expression in colorectal cancer and its sensitivity to oxaliplatin.
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