HLA-DRB1基因对河南汉族不明原因复发性流产患者免疫治疗妊娠结局预测作用  

Predictive value of HLA-DRB1 gene for the treatment of unexplained recurrent spontaneous abortion with paternal lymphocyte alloimmunization therapy in Henan Hans

作　　者：杨科[1] 张冰[1] 廖世秀[1] 何淼[1] 楚艳[1] 李前程[1] 郭谦楠[1] 侯巧芳[1] 丁雪冰[1] 

机构地区：[1]河南省人民医院、郑州大学人民医院、河南省医学遗传研究所,郑州450003

出　　处：《中华医学遗传学杂志》2014年第3期380-382,共3页Chinese Journal of Medical Genetics

基　　金：河南省医学科技攻关计划项目（201303162）

摘　　要：目的初步探索HLA—DRB1基因多态性对河南汉族不明原因复发性流产（unexplainedrecurrentspontaneousabortion，URSA）患者免疫治疗妊娠结局的预测作用。方法对河南汉族300例URSA患者进行淋巴细胞免疫治疗，根据妊娠结局将其分为成功组和失败组。应用序列特异性引物聚合酶链式反应方法对各组患者的HLA—DRB1基因进行基因分型并比较各组之间的频率。结果在接受免疫治疗的URSA患者中，HLA—DRB1＊11的频率在成功组明显低于失败组（0．052 vs．0．110，P〈O．05，OR=0．448），HLA—DRB1＊15的频率在成功组明显高于失败组（0．207VS．0．100，P〈0．05，OR=2．352），其余各等位基因频率在两组间差异无统计学意义。结论对接受免疫治疗的河南汉族URSA患者，携带等位基因HLA—DRB1＊15的患者更易妊娠成功，携带等位基因HLA—DRB1＊11的更易妊娠失败。Objective To explore the value of HLA-DRB1 gene in predicting the outcome of unexplained recurrent spontaneous abortion （URSA） treated with paternal lymphocyte alloimmunization therapy （PLAT） in Henan Hans. Methods Three hundred URSA patients were recruited. Following PLAT treatment, they were divided into two groups according to the outcome of pregnancy. Polymerase chain reaction- sequence specific primer （PCR-SSP） were conducted to analyze the HLA-DRB1 gene. Results For those who have received PLAT treatment, the frequency of HLA-DRB1 ＊ 11 was significantly lower in successfully treated cases than those with abortion （0. 052 vs. O. 110, P〈 O. 05, OR = 0. 448）, whilst the frequency of HLA-DRB1 ＊ 15 was significantly greater in the former （0. 207 vs. O. 100, P〈0.05, OR=2. 352）. Conclusion For patients who have received PLAT treatment, those with HLA-DRB1 ~ 15 are more likely to conceive that those with HLA-DRB1 ＊ 11.

关 键 词：HLA—DRB1 免疫治疗 不明原因复发性流产 妊娠结局 

分 类 号：R714.7[医药卫生—妇产科学] R440[医药卫生—临床医学]