TK1、Ki-67、p53在乳腺癌组织中的表达与及其预后的关系  

Expressions of TK1, Ki-67 and p53 in breast cancer and their relations with prognosis

作　　者：白建平[1] 张霆[1] 秦大伟[1] 

机构地区：[1]中国人民解放军第二五四医院普通外科,天津300142

出　　处：《中国普通外科杂志》2014年第5期629-633,共5页China Journal of General Surgery

摘　　要：目的:探讨TK1、Ki-67、p53在乳腺癌组织中的表达及其与预后的关系。方法:2009年3月—2013年5月收治的60例乳腺癌患者,均接受乳腺癌根治术并留取组织标本,用免疫组化法检测乳腺癌组织及其癌旁组织中TK1、Ki-67和p53的表达;根据随访资料分析TK1、Ki-67和p53的表达与患者预后的关系。结果:乳腺癌组织中TK1、Ki-67、p53阳性率均明显高于癌旁组织(均P<0.05);TK1、Ki-67、p53的表达强度明显影响患者的5年生存率,均表现为表达强度越高患者的生存率越低(均P<0.05);TK1、Ki-67和p53表达的阳性率在术后5年内出现复发或转移的患者中均明显高于无复发或转移的患者(均P<0.05)。结论:在乳腺癌组织中TK1、Ki-67和p53表达增强,且其表达强度与乳腺癌的不良预后密切相关。Objective： To observe the expression of TK1, Ki-67 and p53 in breast cancer （BC） and their prognosis.Methods： Sixty patients with breast cancer admitted from March 2009 to May 2013 underwent radical mastectomy and their histological specimens were obtained. The expressions of TK1, Ki-67 and p53 in these breast cancer tissues and their adjacent tissues were examined by immunohistochemical staining, and in combination with the follow-up data, the relations of TK1, Ki-67 and p53 expression with the prognosis of the patients were analyzed.Results： The positive expression rates of TK1, Ki-67 and p53 in breast cancer tissues were all significantly higher than those in their adjacent tissues （all P〈0.05）. The expression intensities of TK1, Ki-67 and p53 markedly affected the 5-year survival rate of the patients, which all indicated that the higher the expression intensity, the lower the survival rate （all P〈0.05）. The positive expression rates of TK1, Ki-67 and p53 in patients with recurrence or metastasis within 5 years were significantly higher than those in patients without recurrence or metastasis.Conclusion： The expressions of TK1, Ki-67 and p53 are enhanced in breast cancer tissue, and their expression intensities are closely associated with unfavorable prognosis of the patients.

关 键 词：乳腺肿瘤 胸苷激酶1 KI-67抗原 肿瘤抑制蛋白质P53 预后 

分 类 号：R737.9[医药卫生—肿瘤]