等通道挤压超细晶纯钛材料生物安全性研究  

In vitro biocompatibility of equal channel angular processed pure titanium

作　　者：张强[1] 辛海涛[1] 吴玉禄[1] 李恺[1] 寇亚莎[1] 

机构地区：[1]第四军医大学口腔医学院,西安710032

出　　处：《实用口腔医学杂志》2014年第3期302-305,共4页Journal of Practical Stomatology

基　　金：国家自然科学基金(编号:11072261)

摘　　要：目的:初步评价超细晶纯钛的力学和生物学性能。方法:通过等通道挤压(ECAP)模具制备超细晶纯钛,SEM观察晶粒大小,用维氏硬度和万能实验机测定样品硬度和压缩强度并进行细胞毒性实验。结果:经过等通道挤压处理的纯钛,其晶粒直径由40μm减至0.3μm,维氏硬度值由1 496 MPa提高到2 458 MPa;动态、静态压缩屈服强度分别从900、300 MPa提升到1 240、772 MPa。细胞毒性MTT试验显示超细晶纯钛组与晶粒未细化纯钛组均无毒性反应(P>0.05)。结论:纯钛经ECAP处理后,晶粒明显细化,力学性能得到提高,保留了纯钛良好的生物相容性。Objective： To evaluate the biological properties of uhrafine grained pure titanium. Methods： Pure titanium was processed by equal channel angular pressing（ECAP）. The crestlline of the samples was observed and measured under SEM. The hardness was measured by Vicker hardness meter, the compressive strength was measured by universal test machine, the biocompatibility was tested by MTT assay. Results： After ECAP, the crystalline grain diameter decreased from 40 μm to 0.3 μm, the hardness in- creased from 1 496 MPa to 2 458 MPa; dynamic and static compression yield strength increased from 900 MPa and 300 MPa to 1 240 MPa and 772 MPa, respectively, both treated and untreated titanium showed no cytotoxicity （P 〉 0.05）. Conclusion： ECAP processing may decrease the grain size of pure titanium, improve the mechanical properties and keep the biocompatibility.

关 键 词：纯钛 等通道挤压(ECAP) 细胞毒性 口腔修复与种植 

分 类 号：R783.1[医药卫生—口腔医学]