不同比例PLGA/CPC复合支架材料的生物学性能研究  

Biological properties of PLGA /CPC scaffold with different ratio of PLGA to CPC

作　　者：郭冲冲[1,2] 于祥茹[1] 韩晓谦[3] 袁浩天 谷旭[1] 吴哲[1] 

机构地区：[1]吉林大学口腔医院修复科,长春130021 [2]聊城市人民医院口腔科 [3]滨州医学院附属医院口腔科

出　　处：《实用口腔医学杂志》2014年第3期317-321,共5页Journal of Practical Stomatology

基　　金：吉林省自然科学基金(编号:201215052)

摘　　要：目的:评价不同比例的聚乳酸-聚羟基乙酸/磷酸钙骨水泥(PLGA/CPC)复合支架材料物理性能及生物相容性。方法:调整PLGA与CPC的质量比分为8∶2(A组)、7∶3(B组)和6∶4(C组)3组。采用溶剂浇铸-粒子沥滤结合相分离法制备PLGA/CPC复合支架材料,并对3种材料的表面形态、孔隙率、降解性及细胞相容性进行对比研究,筛选出最佳比例复合材料。结果:B组PLGA/CPC复合支架材料孔隙率为91.18%,孔径大小均匀,孔隙间连通性好;降解14 d后,失重率增加;细胞实验表明,该支架材料在第1,3,5,7天时材料毒性均为0级,优于其他2组。结论:7∶3比例PLGA/CPC复合支架材料具备良好的孔径、孔隙率、降解性及生物相容性。Objective： To evaluate the mechanical properties and biocompatibility of PLGA/CPC scaffold with different ratio of PLGA to CPC in vitro. Methods： The samples were prepared by adjusting the mass ratio of the Poly（ lactide-co-glycolide, PLGA） to calci-um phosphate eements（CPC） as 8：2（group A）, 7：3（group B） and 6：4（group C） respectively. The PLGA/CPC scaffold materials were made by solvent casting-particulate leaching/phase separation technique. The pore size, porosity, degradation rate and eytocom- patibility were examined respectively. Results： The scaffold of group B possessed uniform pore distribution, good intereonneetion and high porosity（91.18% ）. After 14 days, the degradation rate and mass loss ratio of the samples of group B were increasing. Cell com- patibility studies showed that the samples of group B had no eytotoxicity. Conclusion： PLGA/CPC scaffold with the ratio of 7：3 has larger pores, higher porosity and better bioeompatibility.

关 键 词：聚乳酸-羟基乙酸 磷酸钙骨水泥 生物相容性 

分 类 号：R318.08[医药卫生—生物医学工程]