降钙素原在胃癌根治术患者术后院内细菌感染中的早期诊断价值  

Value of procalcitonin in early diagnosis of bacterial infection in patients after radical resection for gastric cancer

作　　者：陆辉志 徐亮 

机构地区：[1]武汉市三医院重症医学科,湖北省武汉市430060

出　　处：《世界华人消化杂志》2014年第13期1863-1866,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨降钙素原在胃癌根治术患者术后院内细菌感染早期诊断中的应用.方法:分析2007-06/2012-06重症监护病房收住的胃癌根治术患者86例,根据微生物培养结果分为感染者和非感染者,检测术后血清降钙素原(procalcitonin,PCT)和C反应蛋白(C reactive protein,CRP).结果:在伴有感染时,胃癌根治术患者血清PCT、CRP、白细胞计数、中性粒细胞百分比测定值具有明显升高.PCT>0.5 ng/L作为院内感染的诊断依据时,其敏感度和特异度均优于CRP和白细胞计数.结论:PCT是一个较好的外科感染的诊断指标,能有效地发现早期细菌感染,有助于早期发现院内感染高危患者.AIM： To determine the value of procalcitonin （PCT） in early diagnosis of bacterial infection in patients after radical resection for gastric cancer. METHODS： A total of 86 consecutive patients with resectable gastric cancer were included from June 2007 to June 2012 in our intensive care unit. They were divided into either a noninfection group or an infection group according to microculture results. Plasma levels of PCT and C-reactive protein （CRP） were measured and compared between the two groups. RESULTS： Postoperative values of PCT, CRP, white blood cell （WBC） count and neutrophilic granulocyte percentage were significantly higher in the infection group than in the non-infection group. When PCT 〉 0.5 ng/L was used as the diagnostic basis for postoperative infection in gastric cancer, the sensitivity and specificity of PCT were superior to those of CRP and WBC count; CONCLUSION： PCT is a good marker for identifying early bacterial infection in patients after radical resection for gastric cancer.

关 键 词：降钙素原 C反应蛋白 胃癌 外科感染 

分 类 号：R735.2[医药卫生—肿瘤]