胃丛状纤维黏液瘤临床病理观察  

Clinicopathological characteristics of gastric plexiform fibromyxoma

作　　者：田迅[1] 张玉洁[2] 惠京[2] 宋文静[2] 

机构地区：[1]天津市第二人民医院肝病研究所病理科,天津300192 [2]天津医科大学总医院病理科病理学教研室,天津300052

出　　处：《诊断病理学杂志》2014年第5期280-282,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨胃丛状纤维黏液瘤(PF)的临床病理特征及其鉴别诊断。方法对1例胃PF进行胃镜、组织学观察及免疫组化染色,结合文献讨论其临床病理特点及鉴别诊断。结果患者男性,64岁。左上腹部不适1月余。胃镜示胃窦小弯后壁黏膜下肿物,3.3 cm×2.5 cm大小,边界清晰,表面光滑,色泽正常,顶部凹陷。手术切除肿块。镜下见肿瘤呈多结节状生长,与胃壁平滑肌组织交错分布,富含小的薄壁血管和黏液样基质。肿瘤细胞呈梭形或卵圆形,异型性不明显,未见核分裂象。免疫组化示肿瘤细胞SMA弱(+),CD34、S-100、desmin、CD117和Dog-1(-)。结论胃丛状纤维黏液瘤是一种罕见的有独特组织学特征的胃间叶性肿瘤,熟悉其临床病理学特征有助于与其他胃肠间叶源性肿瘤相鉴别。Objective To explore the clinicopathologic features and differential diagnosis of plexiform fibromyxoma （PF） of stomach. Methods The clinical and pathologic findings of one case of PF were retrospectively analyzed. Immunohistochemieal stains （SP method） were carried out and literature was reviewed. Results A male patient, aged 64 years, complained of left upper abdominal discomfort for more than one month. Endoscopically, the tumor with clear boundary and smooth surface was located at the posterior wall of the gastric antrum, and its size was 3.3 cm × 2.5cm. Histologically, the tumor was rich in small thin-walled blood vessels and myxoid matrix, characterized by multiple nodular growth pattern in the stomach wall. The tumor cells were bland spindle or oval. Immunohistochemically, the tumor cells were weakly positive for SMA, and negative for CD34, S-100, desmin, CDll7 and Dog-1. Conclusions Gastric PF is a rare novel mesenchymal tumor of the stomach. Its distinctively clinicopathologie features can help differentiate this entity from other gastrointestinal mesenchymal tumors.

关 键 词：胃 丛状纤维黏液瘤 丛状血管黏液样肌纤维母细胞肿瘤 胃肠间叶源性肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]