AgOAc为氧化剂制备活性白藜芦醇二聚体衍生物  

Preparation of Active Resveratrol Dimeric Derivatives by Oxidative Coupling Reaction Using AgOAc as Oxidant

作　　者：张元[1,2] 王先分 侯琦[1] 林明宝[1] 姚春所[1] 石建功[1] 

机构地区：[1]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050 [2]河北师范大学化学与材料科学学院,石家庄050024

出　　处：《有机化学》2014年第5期886-892,共7页Chinese Journal of Organic Chemistry

摘　　要：以白藜芦醇为原料,醋酸银为氧化剂在甲醇中进行氧化偶联反应获得了7个白藜芦醇二聚体衍生物1~7.以光谱分析的方法分别确定了它们的结构和相对构型,并讨论了它们可能的形成机理.其中,化合物3,4和5为新的二苯乙烯二聚体衍生物,化合物6和7为首次人工合成的天然产物.所得化合物均进行了体外抗炎活性测试.Oxidative coupling reaction of resveratrol in methanol using silver acetate as oxidant gave seven resveratrol dimeric derivatives 1-7. Their structures and relative configurations were determined on the basis of spectral analysis, and their formation mechanisms were discussed, respectively. Among them, compounds 3, 4 and 5 were determined as new stilbene dimers, and compounds 6 and 7 were synthesized as natural compounds for the first time. All the compounds were evaluated for anti-inflammatory activities.

关 键 词：醋酸银 氧化偶联反应 白藜芦醇二聚体衍生物 抗炎活性 

分 类 号：R914.5[医药卫生—药物化学] TQ460.1[医药卫生—药学]