青岛和丽水地区双生子研究：体育活动和静坐行为的遗传度  

A twin study in Qingdao and Lishui：heritability of exercise participation and sedentary behavior

作　　者：张凤[1] 高文静[1] 余灿清[1] 吕筠[1] 王胜锋[1] 詹思延[1] 胡永华[1] 逄增昌[2] 陈卫健[3] 汪韶洁[2] 陈荣富[3] 曹卫华[1] 李立明[1] 

机构地区：[1]北京大学公共卫生学院流行病与卫生统计学系,100191 [2]青岛市疾病预防控制中心 [3]丽水市疾病预防控制中心

出　　处：《中华流行病学杂志》2014年第6期630-634,共5页Chinese Journal of Epidemiology

基　　金：卫生行业科研专项（201002007）；中华医学基金项目（01-746）；国家自然科学基金（81202264）

摘　　要：目的：探讨山东省青岛和浙江省丽水地区双生子人群体育活动和静坐行为的遗传度。方法使用两地区2004年随访的有卵型信息的双生子人群（共568对，其中青岛242对，丽水326对）横断面调查资料，通过问卷调查得到体育活动和静坐行为信息。采用基于双生子的方差组分分析方法计算双生子表型的遗传度。结果同卵双生子有367对，异卵双生子有201对，双生子中男性571人，女性565人。同卵双生子年龄为（41.14±10.11）岁，异卵双生子年龄为（41.23±9.89）岁。青岛和丽水地区＜40岁人群的体育活动遗传度为78%（35%～96%）、59%（0～94%），≥40岁人群体育活动不受遗传影响。青岛和丽水地区静坐行为遗传度分别为68%（59%～75%）、32%（7%～62%）。结论青岛和丽水地区人群静坐行为水平受遗传影响，且遗传因素在20～40岁人群的体育活动水平中有着重要作用。Objective To investigate both genetic and environmental influences on the exercise participation and sedentary behavior in Qingdao,Shandong province and 326 in Lishui, Zhejiang province. Methods 568 twin pairs,including 242 in Qingdao and 326 in Lishui,were studied. Exercise participation was measured by two questions on the frequency and intensity and then divided into two groups. Sedentary behavior was measured by one question as‘how long do you spend on sitting every day’. Variance component models based on twins was used to estimate the genetic and environmental factors on these traits. Results The average age in monozygotic twins was（41.14 ± 10.11）while in dizygotic twins it was（41.23 ± 9.89）. Genetic factors accounted 78%（35%-96%）and 59%（0-94%）for exercise participation variance in Qingdao and Lishui in people aged between 20 and 40. However,there were no heritability noticed on physical activity in people older than 40 years of age. Rates of heritability on sedentary behavior in Qingdao and Lishui were 68%（59%-75%）and 32%（7%-62%）,respectively. Conclusion Results from the study suggested that sedentary behavior in Chinese people was influenced by genetic factors,which could also explain much of the exercise participation variance in people aged between 20 and 40.

关 键 词：体育活动 静坐行为 遗传度 双生子研究 

分 类 号：R394[医药卫生—医学遗传学]