倍他司汀联合银杏达莫治疗椎基底动脉供血不足的临床疗效观察  

Clinical observation of betahistine combined with Yinxingdamo in the treatment of vertebrobasilar insufficiency

作　　者：张贤春[1] 陈鼎[1] 陈海明[1] 

机构地区：[1]海口市人民医院内科,海口570311

出　　处：《实用药物与临床》2014年第5期587-589,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨倍他司汀联合银杏达莫治疗椎基底动脉供血不足的临床疗效,为临床选择用药方式提供依据。方法选取2011年5月至2013年3月来我院治疗的椎基底动脉供血不足患者86例,随机分为对照组和观察组,观察组采用倍他司汀联合银杏达莫治疗,对照组采用倍他司汀单独治疗,比较两组患者治疗前后基底动脉血液流动速度变化情况。结果治疗前两组患者血液流速比较差异无统计学意义(P>0.05),而治疗后两组均较治疗前明显改善(P<0.05),且治疗组对椎基底动脉血液流动速度改善显著优于对照组(P<0.05)。对照组和观察组的临床有效率分别为72.1%和93.0%,观察组的临床疗效显著优于对照组(P<0.05)。对照组和观察组的不良反应发生率分别为11.6%和9.3%,两组比较差异无统计学意义(P>0.05)。结论倍他司汀联合银杏达莫治疗椎基底动脉供血不足临床疗效显著,不良反应发生率低,值得临床推广应用。Objective To investigate the effects of betahistine combined with Yinxingdamo in the treatment of vertebrobasilar insufficiency. Methods 86 patients with vertebrobasilar insufficiency was selected from May 2011 to March 2013 in our hospital. Patients were divided into control group（betahistine monotherapy） and observation group（betahistine and Yinxingdamo combination therapy）. The blood flow change of basilar artery,clinical effects,and adverse reactions of the two groups were compared. Results The blood flow basilar artery had no significant difference between the two groups at pretreatment（P ＆gt; 0. 05）. Compared with pretreatment,the blood flow basilar artery was significantly increased at posttreatment in the two groups groups（P ＆lt; 0. 05）. However,the blood flow change of basilar artery was significantly better in treatment group than that in control group（ P ＆lt; 0. 05）. The clinical effective rate in control group and treatment group was 72. 1% and 93. 0%,respectively. The clinical effective rate in treatment group was higher than that in control group（P ＆lt; 0. 05）. The adverse reactions rate in control group and treatment group was11. 6% and 9. 3%,respectively. There was no significant difference between the two groups（P ＆gt; 0. 05）. Conclusion Betahistine combined with Yinxingdamo is effective on patients with vertebrobasilar insufficiency with less adverse reactions.

关 键 词：倍他司汀 银杏达莫 椎基底动脉 

分 类 号：R743.3[医药卫生—神经病学与精神病学]