轻度认知功能损害患者血清磷酸化tau蛋白水平变化及其临床意义  

Changes of phosphorylated tau protein level in serum of patients with mild cognitive impairment and its clinical value

作　　者：张媚[1] 熊莉君[1] 肖明月[1] 

机构地区：[1]湖北省武汉市中心医院神经内科,湖北武汉430014

出　　处：《中国现代医学杂志》2014年第11期79-81,共3页China Journal of Modern Medicine

摘　　要：目的研究轻度认知功能损害(MCI)、阿尔茨海默病(AD)患者和正常老年人血清中磷酸化tau蛋白水平以及MCI向AD演变的概率,探讨磷酸化tau蛋白含量变化的临床意义。方法采用双抗体夹心酶联免疫吸附法检测32例MCI患者、30例AD患者和45例正常老年人血清中的磷酸化tau蛋白水平,随访并统计MCI患者在被确诊后的第1年末及第2年末进展成为AD的概率。结果 MCI患者和AD患者血清中磷酸化tau蛋白水平显著高于正常老年人,且差异有统计学意义(均P<0.05),MCI患者与AD患者之间磷酸化tau蛋白水平差异无统计学意义。在MCI确诊后第1年末有4例(12.5%)患者进展为AD,第2年末累计为11例(34.4%)。结论血清中磷酸化tau蛋白水平可以作为诊断MCI的指标,对早期AD也具有临床诊断意义。【Objectives】 To study the level of phosphorylated tau protein in serum of patients with mild cognitive impairment（MCI）, Alzheimers＇ disease（AD） and healthy elders and the morbidity of AD derived from MCI patients, and to explore its clinical value. 【Methods】 The level of phosphorylated tau protein in serum was determined by enzyme linked immunoassay in 32 MCI patients, 30 AD patients and 45 healthy elders. The morbidity of AD derived from MCI patients was investigated after 1 year and 2 years. 【Results】 The level of phosphorylated tau protein in serum of MCI patients and AD patients was significantly higher than that in healthy oldsters（both P〈0.05）, but there is no significant difference between MCI and AD patients（P〉0.05）. The morbidity of AD derived from MCI patients 12.5%（4 cases） after 1 year and 34.4%（total 11 cases） after 2 years. 【Conclusion】 The concentration of phosphorylated tau protein in serum is parameter for diagnosis of both MCI and early AD.

关 键 词：轻度认知功能障碍 阿尔茨海默病 TAU蛋白 血清 

分 类 号：R749.16[医药卫生—神经病学与精神病学]