肺癌组织Lipocalin-2表达与肺癌预后的关系  

Relationship between the expression of Lipocalin-2 and the prognosis of patients with primary lung cancer

作　　者：马小刚[1] 杨晓光[1] 赵峥[1] 

机构地区：[1]河北省邯郸市中心医院胸外科,056001

出　　处：《河北医药》2014年第11期1626-1628,共3页Hebei Medical Journal

摘　　要：目的探讨肺癌组织脂质运载蛋白-2(Lipocalin-2)表达与基质金属蛋白酶-9(MMP-9)、肿瘤侵袭转移及预后的关系。方法采用免疫组织化学SP法检测Lipocalin-2、MMP-9在55例肺癌组织及40例正常肺组织的表达,分析其表达与临床病理特征、复发率间的关系。采用Western blot检测Lipocalin-2在肺鳞癌和腺癌组织的表达差异。结果 Lipocalin-2、MMP-9在肺癌组织的阳性表达率显著高于正常肺组织,差异有统计学意义(P<0.05),且Lipocalin-2表达与MMP-9呈显著正相关(r=0.586,P<0.05)。Lipocalin-2阳性表达率随着肿瘤TNM临床分期的增高及淋巴结远处转移而增高。Lipocalin-2高表达者术后3年肺癌复发率显著高于低表达者,差异有统计学意义(P<0.05)。Lipocalin-2在肺腺癌组织的表达高于鳞癌组织,差异有统计学意义(P<0.05)。结论肺癌组织Lipocalin-2的异常高表达参与了肿瘤的侵袭转移过程,可作为预后判断的指标。Objective To investigate the expression of Lipocalin-2 and its relationship with MMP-9 as well as prognosis of patients with primary lung cancer .Methods The expression levels of Lipocalin-2 and MMP-9 were detected by immunohistochemistry （ SP） in 55 cases of lung cancer tissues and 40 cases of normal lung tissues .The relationship between Lipocalin-2 expression and clinicopathological features of lung cancer as well as relapse rate was analyzed .Western blot was used to detect the expression of Lipocalin-2 in lung adenocarcinoma and lung squamous carcinoma .Results The positive expression rates of Lipocalin-2 and MMP-9 in lung cancer tissues were significantly higher than those of normal lung tissues （P 〈0.05）,furthermore,the expression of Lipocalin-2 was positively correlated to that of MMP-9（ r =0.586, P 〈0.05）. The positive expression rate of Lipocalin-2 was increased ,with the increase of clinical stage and lymph node metastasis of lung cancer.The 3-year relapse rate after operation in patients with higher expression of Lipocalin -2 was significantly higher than that in patients with lower expression of Lipocalin-2（ P 〈0.05）.The expression levels of Lipocalin-2 in lung adenocarcinoma were significantly higher than those in lung squamous carcinoma （ P 〈0.05）.Conclusion The overexpression of Lipocalin-2 plays an important role in the invasion and metastasis of primary lung cancer , which can be used as a index for evaluating prognosis of patients with lung cancer .

关 键 词：肺肿瘤 脂质运载蛋白-2 预后 

分 类 号：R734.2[医药卫生—肿瘤]