HLA-B27检测对强直性脊柱炎诊断的临床意义  

Clinical significance of HLA-B27 detection in diagnosis of ankylosing spondylitis

作　　者：刘永杰[1] 张小芳[2] 张运刚[2] 李海新[2] 李守霞[2] 

机构地区：[1]邯郸市中心医院器械科,河北邯郸056001 [2]邯郸市中心医院检验科,河北邯郸056001

出　　处：《国际检验医学杂志》2014年第10期1285-1286,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨人类白细胞抗原（HLA）-B27对强直性脊柱炎（AS）的诊断价值。方法选择2 768例疑诊AS患者作为研究对象,其中600例为确诊AS患者。采用流式细胞术进行血HLA-B27检测。结果 2 768例疑诊AS的患者中,HLA-B27阳性598例（21.6%）,阴性2 170例（78.4%）。男、女性患者HLA-B27阳性率的差异有统计学意义（P〈0.05）;20~〈40岁的AS疑诊患者HLA-B27阳性率显著高于其他年龄段的阳性率（P〈0.05）。600例AS确诊患者中,HLA-B27阳性536例（89.3%）。结论 HLA-B27检测结合临床表现有助于AS的早期诊断。Objective To investigate the diagnostic value of human leukocyte antigen （HLA ）-B27 for ankylosing spondylitis （AS） .Methods 2 768 patients with suspected AS were enrolled ,including 600 patients with confirmed AS .Flow cytometry was performed to detect blood HLA-B27 .Results Among 2 768 patients with suspected AS ,598（21 .6% ） patients were found HLA-B27 positive and 2 170（78 .4% ） patients negative .Difference of HLA-B27 positive rates between male and female patients was sta-tistically significant（P〈 0 .05） .HLA-B27 positive rate of patients aged 20 - 〈 40 years was significantly higher than the others （P〈0 .05） .Among 600 patients with confirmed AS ,536 cases（89 .3% ） was found HLA-B27 positive .Conclusion HLA-B27 de-tection combined with clinical manifestations contribute to early diagnosis of AS .

关 键 词：流式细胞术 脊柱炎 强直性 HLA抗原 

分 类 号：R593.23[医药卫生—内科学]