大鼠免疫性和酒精性肝病的形态学变化  

Morphology of immune and alcohlic liver diseases in rats

作　　者：簿爱华 田翠时[1] 薛贵平[1] 杜建华[1] 许永利[1] 

机构地区：[1]张家口医学院超微病理教研室,河北省张家口市075029

出　　处：《世界华人消化杂志》2001年第2期157-160,共4页World Chinese Journal of Digestology

摘　　要：目的探讨免疫性肝病(ILD)和酒精性肝病(ALD)的形态学变化,为临床治疗提供形态学依据。方法猪血清注射法,连续8wk致大鼠ILD;饮用酒精200mL·L^1,8wk致大鼠ALD;在光镜和电镜下观察肝脏形态变化。结果 ILD和ALD组肝细胞膜受损。肝细胞质内脂质包含物明显增多。ILD组肝内胶原纤维明显增生,假小叶形成。肝细胞器减少;线粒体膜破损,嵴减少,贮脂细胞数目增加,胞质内α-平滑肌肌动蛋白阳性。ILD组呈现肝纤维化特征,ALD组肝组织大量局灶性坏死和肝细胞水肿;Mallory小体和嗜酸性小体形成,并且有大量炎细胞浸润。结论两种肝病形态学改变不同,治疗ILD应以抗肝纤维化为主,而治疗ALD应以活血抗炎为主。AIM To study the morphological changes of immune liver injury and alcoholic liver disease. METHODS Rats were administrated intra-abdominally swine serum for 8 weeks to induce immune liver disease (ILD) and alcohol (20%) drinking for 8 weeks to induce alcoholic liver disease (ALD). Liver specimens were taken for light and electron microscopic examination. RESULTS The lipid contents increased in liver cells, thestructure of liver cell membrane were destroyed in ILD and ALD groups. The collagen fibrils had significant hyperplasia, and false liver acinus formed in liver of ILD. The organelles of liver cells were decreased. The membrane of mitochondrion were destroyed, and mitochondrion cristea decreased. The number of fatstoring cells (FSC) increased, and the α-SMA was positive in the FSC. The liver was fibrotic in ILD group. Focal necrosis and edema of liver cells were found in the liver of ALD group. The Mallory bodies and eosinophilous bodies formed, with a large number of inflammation cells infiltration in the liver of ALD group. CONCLUSION The morphological changes of liver were different between ILD and ALD. The priority treatment for ILD was antifibrosis, but for ALD was invigorating the blood circulation and resisting inflammation.

关 键 词：病理学 肝疾病 免疫性疾病 酒精性 WISTAR 

分 类 号：R575[医药卫生—消化系统]