赤芍与白芍脐中穴给药的药理作用比较研究  

Pharmacological Effects in Comparison between Radix Paeoniae Rubra and Radix Paeoniae Alba Umbilical Acupuncture Points

作　　者：吴修红[1] 胡妮娜[1] 李宝龙[1] 周海纯[1] 杨恩龙[1] 张淑香[1] 周忠光[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《针灸临床杂志》2014年第5期54-56,共3页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家科技支撑计划项目;编号:2006BAI09B08-10;国家自然科学基金项目;编号:81373931;黑龙江省中医管理局项目;编号:ZHY10-Z01;ZHY10-W26;哈尔滨市创新人才基金项目;编号:2012RFLXS012;黑龙江中医药大学创新人才计划项目;编号:2012RCD07;2012jc01

摘　　要：目的:探讨赤芍与白芍脐中穴给药药理作用差异。方法:选择脐中穴为给药部位,考察赤芍、白芍贴膏剂脐中穴贴敷对二甲苯所致小鼠耳肿胀、醋酸致小鼠扭体反应以及ADP和凝血酶诱导的血小板聚集的影响。结果:与空白对照组比较,赤芍贴膏剂组有显著的镇痛和抑制血小板聚集作用(P<0.05),白芍贴膏剂组具有显著的镇痛作用(P<0.05),散结镇痛胶囊及桂枝茯苓贴膏剂有显著的抗炎、镇痛及抗血小板聚集作用(P<0.05),赤芍、白芍贴膏剂组对二甲苯致小鼠耳肿胀和空白组相比虽无显著性差异,但都呈一定作用趋势。桂枝茯苓贴膏剂组与赤芍贴膏剂组相比,也都有作用增强趋势,但无显著性差异。结论:赤芍脐中穴给药具有止痛、抗血小板聚集作用,白芍脐中穴给药具有止痛作用。Objective： To explore the effect of difference between radix paeoniae rubra and radix paeoniae alba in the umbilical acupuncture point for pharmacological action. Methods：Select the umbilical acupuncture point for drug delivery. Investigate radix paeoniae rubra, radix paeoniae alba emplastrum umbilical acupuncture point sticking on mice ear swelling caused by dimethylbenzene, acetic acid in mice body torsion reaction and the in- fluence of the platelet aggregation induced by ADP and thrombin. Results：Compared with blank control group, radix paeoniae rubra emplastrum group had significantly analgesic action and inhibited platelet aggregation （ P 〈 0.05 ） ; Radix paeoniae alba emplastrum group had a significantly analgesic action（P 〈0.05 ） ; Sanjie analgesic capsule and cassia twig tuckahoe emplastrum had an obvious anti - inflammation and analgesic action and platelet aggregation （P 〈 0. 05 ） ; Radix paeoniae rubra, radix paeoniae alba emplastrum group on mice ear swelling induced by xylene and compared with blank group, there was no significant difference, but all showed a trend of effects. Cassia twig tuckahoe emplastrum group and radix paeoniae rubra emplastrum compared group, also had an effect on enhancing trend, but there was no bilical acupuncture point has analgesic action, significant difference. Conclusion：Radix paeoniae rubra in umanti platelet aggregation, and root of herbaceous peony in the um- bilical acupuncture point to medicine has an analgesic effect .

关 键 词：赤芍 白芍 脐中穴 镇痛 抗血小板聚集 

分 类 号：R224.2[医药卫生—中医基础理论]