被动吸烟与膀胱癌相关性的多中心病例对照研究  

A multicenter case-control study of the relationship between passive smoking and bladder cancer

作　　者：周玉华[1] 秦国强 毕学成[3] 韩兆冬 戴奇山 何慧婵 江福能 钟惟德 

机构地区：[1]广州医科大学附属广州市第一人民医院病案室,广州510180 [2]番禺区中心医院,广州511400 [3]广东省人民医院,广州510080 [4]泌尿外科和广东省临床分子医学及分子诊断重点实验室

出　　处：《新医学》2014年第5期300-303,共4页Journal of New Medicine

基　　金：广东省科技计划项目(2006B36030011);国家自然科学基金青年项目(81200550)

摘　　要：目的研究被动吸烟与膀胱癌发生的关系。方法运用多中心病例对照研究,收集、整理432例原发性膀胱癌患者和392例非膀胱癌患者的资料,并进行统计分析。结果暴露在公共场所吸烟环境中的被动吸烟者发生膀胱癌风险随着接触烟草时间增加,最大优势比在出现在被动吸烟每日至少2次者(OR=1.88),每日接触烟草者发生膀胱癌的可能性大(P=0.048),但每日被动吸烟1次与2次以上者比较差异无统计学意义(P>0.05);所有时期在家中被动吸烟者均出现膀胱癌风险增加,最大优势比出现在儿童期(OR=3.71),其与从未在家中被动吸烟者相比发生膀胱癌的可能性明显增高(P<0.01),但各时期间比较差异未见统计学意义(P>0.05)。结论被动吸烟是膀胱癌的危险因素,减少被动吸烟尤其是儿童期被动吸烟是预防膀胱癌的有效方法之一。Objective To investigate the relationship between passive smoking and the occurrence of bladder cancer. Methods A multicenter casecontrol study included 432 patients with bladder cancer and 392 patients without bladder cancer was conducted,and the information about patients of passive smoking was col-lected for statistical analysis. Results The risk of bladder cancer increased with the time exposed to tobacco smoking in public. The biggest odds rate （OR）occurred in those who were exposed to tobacco smoke at least twice per day （OR=1.88）. The occurrence of bladder cancer was significantly higher in people who contact tobacco smoking daily （P=0.048）,but there was no statistical significance between passive smokers exposed to smoking once a day and at least twice a day. The risk of bladder cancer increased in all periods,the biggest OR in children period （OR=3.71 ）,the occurrence of bladder cancer among whom was significantly higher when compared with nonpassive smokers at home （P〈0.01 ）. Conclusion Passive smoking is a risk factor for bladder cancer,reducing passive smoking especially during childhood is an effective way to prevent bladder cancer.

关 键 词：被动吸烟 膀胱癌 

分 类 号：R737.14[医药卫生—肿瘤]