环孢菌素A联合化疗治疗难治性急性髓性白血病疗效观察  

Efficacy of cyclosporin A combined with chemotherapy in treatment of refractory and relapsed acute myeloid leukemia

作　　者：夏文春 王清霞[1] 李丹[1] 吕福刚[1] 

机构地区：[1]吉林市人民医院血液科,吉林吉林132001

出　　处：《中国热带医学》2014年第4期501-502,共2页China Tropical Medicine

摘　　要：目的观察环孢菌素A联合化疗治疗难治性急性髓性白血病疗效。方法治疗组70例患者采用粒细胞集落刺激因子＋亚砷酸＋环孢菌素A化疗前1d应用,阿糖胞苷第1-7d,米托蒽醌第5-7d即MA（7＋3）的化疗方案化疗。对照组67例患者采用常规的阿糖胞苷第1-7d,蒽环类化疗药物（米托蒽醌或柔红霉素）第1-3d即MA或DA（3＋7）的化疗方案化疗。结果治疗组完全缓解率（Complete remission rate,CR）为71.4%,对照组CR为46.2%,治疗组总缓解率（Total Remission rate,TR）为87.1%,对照组TR为67.1%。治疗组缓解率与对照组相比,CR及TR差异均有统计学意义（P值均〈0.01）。结论环孢菌素A＋亚砷酸＋粒细胞集落刺激因子联合化疗方案MA（7＋3）能明显提高复发难治急性髓系白血病完全缓解率,显著降低病死率,经济实用,便于临床应用。Objective To investigate the efficacy of cyclosporin A combined with chemotherapy in treatment of refractoryand relapsed acute myeloid leukemia.Methods Granulocyte colony stimulating factor plus arsenious acid and cyclosporin Awere used to the 70 refractory and relapsed acute myeloid leukemia patients in the observation group a dy before chemotherapy,then followed by chemotherapy with cytarabine for 1-7 days and mitoxantrone for 5-7days（7＋3chemotherapy regimen）. The67 cqases in the control group were treated with cytarabine for 1-7 days and mitoxantrone for 1-3 days（ That is the 3＋7 dayregimen）. Results The complete remission rate（CR） for treatment group and the control group were 71.4% and 46.2%. Thetotal remission raqte（TR） for the treatment group and the control group were 87.1%,and 67.1%. Compared with the controlgroup the CR and TR values in treatment group were significantly different（P0.01）. Conclusions Cyclosporin A incombination with other drugs is effective for treatment of refractory and relapsed acute myeloid leukemia with high completeremission rate and low death rate suitable for clinical application.

关 键 词：难治性复发性急性髓性白血病 环孢素A 亚砷酸 粒细胞刺激因子 化疗 

分 类 号：R733.72[医药卫生—肿瘤]