甲钴胺预防紫杉醇神经毒性疗效观察  

Effect of mecobalamin in preventing paclitaxe-induced peripheral neurotoxicity in cancer patients

作　　者：陈婵娟[1] 陈昌南[1] 潘岐作[1] 张呈[1] 谢峰[1] 

机构地区：[1]江门市新会区人民医院内三区,广东江门529100

出　　处：《中国热带医学》2014年第4期508-509,共2页China Tropical Medicine

摘　　要：目的探讨甲钴胺预防紫杉醇联合铂类化疗所致神经毒性的效果。方法对80例经病理确诊为恶性肿瘤的患者,随机分成两组各40例,两组患者均接受紫杉醇联合铂类的标准化疗4程,观察组在化疗基础上给予甲钴胺片500μg,口服,每天三次。观察两组患者的神经毒性反应。结果观察组外周神经毒性反应I度10例,II度1例,III度1例,IV度0例,神经毒性发生率为30%;对照组相应级别神经毒性反应分别是14、4、3、0例,神经毒性发生率为52.5%。两组神经毒性发生率比较差异有统计学意义(χ2=-2.084,P<0.05)。结论甲钴胺预防紫杉醇化疗所致神经毒性疗效肯定。Objective To investigate the effect of mecobalamin in preventing paclitaxe and platinum-induced peripheralneurotoxicity（CIPN） in cancer patients.Methods Eighty cancer patients were randomly divided into observation groupand control group each comprised 40 cases. The cases in both groups were treated with paclitaxe and platinum chemotherapyfor four courses. The cases in observation group were orally given mecobalamin 500μg, three times daily, then the incidence ofCIPN in two groups were observed and analyzed. Results Degree I,II, III and IV reactions occurred to 10,1,1 and o cases inthe observation groups with an incidence of 30%, and that occurred to 14, 4, 3 and 0 cases in the control group, with theincidence of 52.5%, showing significant differences（χ^2=- 2.084,P0.05）. Conclusion Chemotherapy combined withmecobalamin can effectively prevent CIPN in cancer patients treated with paclitaxe.

关 键 词：甲钴胺 紫杉醇 恶性肿瘤 神经毒性 

分 类 号：R730.5[医药卫生—肿瘤]