射频消融治疗局部晚期胰头癌疗效分析  

Efficacy of radiofreqency ablation on locally advanced pancreatic head cancer

作　　者：陈升阳[1] 李晓勇[1] 陈艳军[1] 杨战锋[1] 崔卫东[1] 周百中[1] 宋伟华[1] 

机构地区：[1]郑州大学第五附属医院肝胆胰腺外科,郑州450052

出　　处：《郑州大学学报（医学版）》2014年第3期341-344,共4页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省教育厅自然科学研究项目2011A320036

摘　　要：目的：评价射频消融（ RFA）治疗局部晚期胰头癌的临床疗效。方法：将87例局部晚期胰头癌患者分为两组，一组给予RFA联合胆肠及胃肠旁路吻合术（RFA组，n＝42），另一组给予单纯胆肠及胃肠吻合术（对照组， n＝45）；随访3～50个月，比较治疗前与治疗3个月后血清CA19-9和CA242水平的变化，应用Kaplan-Meier法绘制生存曲线并进行log-rank检验。结果：RFA组治疗3个月后血清CA19-9和CA242水平均较对照组下降更明显（ t＝10．589、6．130，P＜0．001）。两组患者生存曲线差异有统计学意义（χ2＝33．152，P＜0．001）；RFA组1、2、3 a生存率分别为77．9％、28．7％、2．4％，中位生存期为21个月（95％置信区间17．86～24．14个月）；对照组1、2、3 a生存率分别为22．9％、2．2％、0．0％，中位生存期为10个月（95％置信区间8．90～11．10个月）。结论：RFA能够有效延长局部晚期胰头癌患者的生存期。Aim：To evaluate the clinical efficacy of radiofreqency ablation （ RFA） on locally advanced pancreatic head cancer（LAPHC）.Methods：A total of 87 LAPHC patients were divided into RFA group （n=42） and control group（n=45）,and followed up for 3-50 months.The serum CA19-9 and CA242 levels preoperation and 3 months after operation were determined .Survival curve was drown by the Kaplan-Meier method .Results：The descent range of serum CA 19-9 and CA242 levels of RFA group 3 months after operation were more than that of the control group （ t=10.589,6.130,P〈0.001）.The survival curve of RFA group differed from that of the control group （χ2 =33.152,P〈0.001）.The 1-,2-and 3-year overall cumulative survival rates in RFA group and control group were 77.9%,28.7%,2.4%and 22.9%,2.2%, 0.0%,respectively;the median survival time was 21 months（95%CI was 17.86-24.14 months） in RFA group and 10 months（95%CI was 8.90-11.10 months） in control group,respectively.Conclusion： RFA can effectively prolong sur-vival time of patients with LAPHC .

关 键 词：胰头癌 射频消融 肿瘤标记物 生存分析 

分 类 号：R735.9[医药卫生—肿瘤]