上皮性卵巢癌组织中IMP1的表达  

Expression of IMP1 in epithelial ovarian cancer tissue

作　　者：李留霞[1] 李冰熠 李秀芳[1] 张兰兰[1] 王凯娟[2,3] 张建营[2,3] 

机构地区：[1]郑州大学第一附属医院妇产科,郑州450052 [2]郑州大学公共卫生学院,郑州450001 [3]河南省肿瘤流行病学重点实验室,郑州450052

出　　处：《郑州大学学报（医学版）》2014年第3期374-377,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨上皮性卵巢癌组织中IMP1蛋白及mRNA的表达情况。方法:采用免疫组化方法和RT-PCR技术检测47例上皮性卵巢癌、28例卵巢上皮性良性肿瘤及20例正常卵巢上皮组织中IMP1蛋白和mRNA的表达情况。结果:IMP1蛋白在上皮性卵巢癌、卵巢上皮性良性肿瘤及正常卵巢上皮组织中的阳性表达率分别为85.1%、32.1%及10.0%,IMP1 mRNA在上述3种组织中的相对表达量分别为(0.652±0.067)、(0.120±0.013)、(0.085±0.011)(χ2=39.239,F=990.674,P均<0.001);且上皮性卵巢癌组织中IMP1蛋白阳性表达率、mRNA相对表达量均高于其他2种组织(P均<0.001)。不同FIGO分期和组织学分级的上皮性卵巢组织中IMP1蛋白的阳性表达率比较,差异有统计意义(χ2校正=5.645、4.365,P均<0.05)。上皮性卵巢癌组织中IMP1蛋白与mRNA表达呈正相关(rS=0.869,P<0.001)。结论:IMP1可能参与卵巢癌的发生发展过程。Aim：To detect the expression of IMP 1 in epithelial ovarian cancer tissue .Methods：The IMP1 protein and mRNA expression levels in 47 cases of epithelial ovarian cancer ,28 cases of benign ovarian disease and 20 cases of normal o-varian were respectively measured by immunohistochemistry and RT-PCR.Results：There were significant differences in the expressions of IMP1 protein and mRNA in three kinds of epithelial ovarian tissue [85.1%,32.1%,10.0%,χ2 =39.239,P〈0.001;（0.652 ±0.067）,（0.120 ±0.013）,（0.085 ±0.011）,F=990.674,P〈0.001], and the expressions of IMP1 pro-tein and mRNA in epithelial ovarian cancer tissue were higher than those of the other two kinds of tissue （P〈0.001）.The expression in epithelial ovarian cancer tissue was associated with FIGO staging and histological grading （χ2adjust =5.645,4.365, P〈0.05）.The IMP1 protein expression was positively related with IMP 1 mRNA expression in epithelial ovarian cancer tissue （rS =0.869,P〈0.001）.Conclusion：IMP1 may be involved in the progress of epithelial ovarian cancer .

关 键 词：上皮性卵巢癌 IMP1 

分 类 号：R737.31[医药卫生—肿瘤]