高分子量细胞角蛋白在前列腺癌中表达的临床意义  

Significance of expression of high molecular weight cytokeratin in prostate adenocarcinoma

作　　者：闫洪涛[1] 唐朴[2] 杨红[1] 

机构地区：[1]四川省人民医院,四川成都610072 [2]成都中医药大学附属医院,四川成都610072

出　　处：《四川医学》2001年第3期230-231,共2页Sichuan Medical Journal

摘　　要：目的　提高对前列腺良、恶性病变的认识和鉴别诊断水平。方法　用免疫组织化学染色方法分别对 2 13例前列腺良、恶性病变组织作了抗高分子量细胞角蛋白抗体 (34BE12 )染色 ,特异地显示前列腺基底细胞。结果　前列腺腺癌基底细胞均丢失 ,而前列腺增生性病变基底细胞绝大多数保存完好 ,只有少数 3级前列腺上皮内肿瘤和非典型性瘤样增生基底细胞不完整。结论　能特异显示前列腺基底细胞的 34BE12抗体在前列腺良、性病变的诊断和鉴别 ,以及对前列腺癌的早期诊断中均有很好应用价值。Objective To understand the characteristics of benign and malignant prostate lesions and improve the differential diagnosis.Methods Immunohistochemical method was adopted.213 benign and malignant prostatic tissues were stained with high molecular weight cytokeratin monoclonal antibody 34BE12 to specifically indicate the basal cells.Results The basal cell layer was lost in all the prostate adenocarcinomas ,but it remained in most proliferative lesions,except for a few cases of a typical adenomatous hyperplasia and grade 3 in traepithelial neoplasia in which the basal layer was disrupted.Conclusion The above results demonstrate that 34BE12 antibody is useful in the diagnosis and differential diagnosis of benign and malignant prostate lesions.

关 键 词：前列腺癌 高分子量细胞角蛋白抗体 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]