注射用磷酸川芎嗪对脑梗死患者梗死灶面积及神经功能的干预作用观察  

Intervention Effect of Ligustrazine Phosphate for Injection on the Infarct Size and Neurological Function in Patients with Cerebral Infarction

作　　者：许洪亮[1] 李军[1] 

机构地区：[1]莱芜市人民医院,山东莱芜271199

出　　处：《中国药房》2014年第23期2173-2175,共3页China Pharmacy

摘　　要：目的:观察注射用磷酸川芎嗪对脑梗死患者梗死灶面积及神经功能的干预作用。方法:将110例脑梗死患者按照前瞻性随机开放法分为对照组和观察组,每组55例。对照组采取脑梗死常规治疗方案,观察组在常规治疗基础上加用磷酸川芎嗪注射液,两组疗程均为2周。结果:治疗后观察组总有效率为83.6%,对照组总有效率为72.7%,两组比较差异有统计学意义(χ2=4.633,P<0.05);治疗后两组各血脂指标均有不同程度改善,其中观察组总胆固醇(TC)和低密度脂蛋白(LDL)水平均低于对照组,差异有统计学意义(t分别为11.177和12.872,P<0.05);治疗后两组梗死灶面积及NIHSS评分均有所改善,其中观察组的大面积、小面积梗死灶改善率分别为57.1%和36.7%,高于对照组的16.7%和10.3%,差异有统计学意义(χ2分别为35.272和11.537,P<0.05);观察组的NIHSS评分低于同期对照组,差异有统计学意义(t=6.801,P<0.05)。结论:注射用磷酸川芎嗪能明显缩小脑梗死患者梗死灶面积,并能修复患者的神经功能。OBJECTIVE： To observe the intervention effect of Ligustrazine phosphate for injection on the infarct size and neurological function in patients with cerebral infarction. METHODS： 110 patients with cerebral infarction were randomly divided into control group and observation group with 55 cases in each group. Control group took conventional treatment of cerebral infarction, and the observation group was additionally given Ligustrazine phosphate injection based on the conventional treatment. Treatment course lasted for 2 weeks. RESULTS： After treatment, the total effective rate was 83.6% in observation group and 72.7% in control groups; there was statistical significance （X^2=4.633, P〈0.05）. The serum lipid of 2 groups were improved to different extent after treatment; the levels of TG and LDL in observation group were lower than in control group; there was statistical significance （t= 11.177, 12.872, P〈0.05）. After treatment, infarct size and NIHSS scores were improved in 2 groups, and improvement rates of large area infarction and small area infraction were 57.1% and 36.7 %, respectively, which were significantly higher than 16.7 % and 10.3% of control group; there was statistical significance （X^2=35.272, 11.537,P〈0.05）. NIHSS score of observation group was significantly lower than that of control group; there was statistical significance （t= 6.801, P〈 0.05）. CONCLUSIONS： Ligust- razine phosphate for injection can significantly reduce infarct size in patients with cerebral infarction and repair the neurological function of patients.

关 键 词：注射用川芎嗪 脑梗死 神经功能 

分 类 号：R364.17[医药卫生—病理学] R283.611[医药卫生—基础医学]