TAAR6基因多态性与精神分裂症关联性的Meta分析  

Meta-analysis on relationship between TAAR6 gene polymorphisms and schizophrenia

作　　者：俞琼[1] 张瑞明[2] 姜媛[3] 王猛[2] 于雅琴[1] 史杰萍[1] 

机构地区：[1]吉林大学公共卫生学院流行病与卫生统计学教研室,吉林长春130021 [2]吉林大学公共卫生学院 [3]四川大学华西公共卫生学院流行病学教研室,四川成都610041

出　　处：《吉林大学学报（医学版）》2014年第3期633-640,共8页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(30901229)

摘　　要：目的：探讨人群中TAAR6基因多态性与精神分裂症的关联，阐明 TAAR6基因与精神分裂症的关系。方法：通过计算机检索PubMed、Cochrance、中国知网（CNKI）和万方数据库，检索 TAAR6基因多态性与精神分裂症关联的相关文献。检索时间为1994年1月-2013年5月公开发表的文献。根据纳入标准对相关文献进行筛查，选出合适的文献，提取文献中的数据。以比值比（OR）和95％可信区间（95％CI）为效应指标。采用RevMan 5.1软件对各项研究原始数据进行统计学分析，包括异质性检验、合并效应量以及评估发表偏倚。结果：按照纳入标准共有5篇文献符合条件，共选取了5个位点进行 Meta分析，rs8192625位点的等位基因合并 OR＝0.93，95％CI＝0.81～1.07，P＝0.32；基因型合并 OR＝0.88，95％CI＝0.76～1.02，P＝0.08。rs4305745等位基因合并 OR＝0.96，95％CI＝0.90～1.03，P＝0.29；基因型合并 OR＝1.03，95％CI＝0.92～1.14，P＝0.62。rs6903874位点的等位基因合并 OR＝0.95，95％CI＝0.86～1.04，P＝0.27；基因型合并 OR＝0.93，95％CI＝0.84～1.04，P＝0.20。rs6937506位点的等位基因合并 OR＝0.95，95％CI＝0.86～1.04， P＝0.27；基因型合并 OR＝0.93，95％CI＝0.83～1.03，P＝0.17。rs7772821位点的等位基因合并 OR＝0.96，95％CI＝0.87～1.05，P＝0.35；基因型合并 OR＝0.96，95％CI＝0.86～1.07，P＝0.47。结论：人群中TAAR6基因5个位点的等位基因和基因型多态性与精神分裂症无关联，提示 TAAR6基因多态性可能与精神分裂症无关联。Objective To explore the relationship between trace amine associated receptor 6 （TAAR6 ） gene polymorphisms and schizophrenia, and to clarify association between the TAAR6 gene and schizophrenia. Methods PubMed,Cochorane,CNKI and Wanfang Database were used to search all the relevant case-control trials of full text about the relationship between TAAR6 gene polymorphisms and schizophrenia. According to inclusion criteria, the appropriate papers and extracted data from the studies were chosen. The results were expressed as odds ratios （OR）and their 95% confidence intervals （CI）. Statistic analysis was performed with RevMan 5.1 including the heterogeneity inspection, effect consoliating and evaluatation on publication bias.＆amp;nbsp;Results According to inclusion criteria,5 studies were selected and 5 SNPs were chosen for Meta-analysis.The Meta-analysis results showed that there was no significant association between schizophrenia and the SNPs （rs8192625 allele：OR=0.93,95%CI=0.81-1.07,P=0.32.rs8192625 genotype：OR=0.88,95%CI=0.76-1.02,P=0.08.rs4305745 allele：OR=0.96,95%CI =0.90-1.03,P=0.29;rs4305745 genotype：OR=0.95,95% CI =0.86-1.04,P=0.27.rs6903874 allele：OR=0.95, 95%CI=0.86-1.04,P=0.27;rs6903874 genotype：OR=0.93,95%CI =0.84-1.04,P=0.20;rs6937506 allele：OR=0.955,95%CI =0.86-1.04,P=0.27;rs6937506 genotype：OR=0.93,95% CI =0.83-1.03,P=0.17.rs7772821 allele：OR=0.96, 95%CI=0.87-1.05,P=0.35;rs7772821 genotype：OR=0.96, 95%CI=0.86-1.07,P=0.47）.Conclusion The allelic and genetic polymorphisms of five sites in TAAR6 gene are not associated with schizophrenia, which indicates that there is no relationship between TAAR6 gene polymorphisms and schizophrenia.

关 键 词：TAAR6 基因 基因多态性 精神分裂症 META分析 

分 类 号：Q75[生物学—分子生物学] R749.3[医药卫生—神经病学与精神病学]