胆固醇/卵磷脂/壳聚糖体系中碳酸钙模拟生物矿化的研究  

The Study on Calcium Carbonate Mimetic Biomineralization in the Chitosan/Phospholipid/Cholesterol System

作　　者：王静梅[1] 姚松年[1] 

机构地区：[1]武汉大学分析测试中心,武汉430072

出　　处：《无机化学学报》2001年第2期202-208,共7页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目!(No.29473113)

摘　　要：本文采用X射线衍射、红外光谱和扫描电子显微镜等方法研究了胆固醇／卵磷脂／壳聚糖体系中碳酸钙模拟生物矿化过程。通过改变有机基质的组成，使有机基质的模板作用也发生改变，从而使生成方解石型碳酸钙的模板可生成球霰石型的碳酸钙。文中还进一步探讨了体系中壳聚精、卵磷脂、胆固醇三者的协同作用对生成碳酸钙晶型的影响。The process of calcium mimetic biomineralization in the chitosan-phospholipid-cholesterol system is reported in this paper, and is charasterized by using XRD, SEM and IR. The model action is changed through changing the composition of organic base. Vaterite can be created in organic base in which calcite was created before. Keeping the ratio of phospholipid and cholesterol constant, the largest quantity of vaterite can be gained as chitosan concentration is 4g' L-l. When chitosan concentration is constant, with the ratio of phospholipid and cholesterol increasing, more vaterite can be gained. The template of biomimeralization can be assumed due to that the action of chitosan could be modified by phospholipid and cholesterol, and the surface of forming crystal is changed to higher energy surface. So the vaterite with high energy can be gained easily. At last we think that the largest quantity of vaterite can be gained when chitosan, phospholipid and cholesterol are in existence with a proper ratio.

关 键 词：碳酸钼 胆固醇 卵磷脂 壳聚糖 生物矿化 

分 类 号：O636.1[理学—高分子化学] O614.231[理学—化学]