肝癌组织中Ki-67表达水平及微血管密度与患者年龄的相关性  

Correlation between patient＇s age and expression of Ki-67 or microvessel density in the tissues ofhuman hepatocellular carcinoma

作　　者：罗旻[1] 曹颖[2] 文安智[2] 

机构地区：[1]贵州省人民医院肿瘤科,贵阳550002 [2]贵州省人民医院病理科,贵阳550002

出　　处：《肿瘤研究与临床》2014年第5期322-324,共3页Cancer Research and Clinic

摘　　要：目的探讨原发性肝癌中Ki-67表达水平及微血管密度（MVD）与患者年龄的相关性。方法应用免疫组织化学法检测肝癌切除标本癌组织Ki-67表达水平及MVD，并分析其与年龄的相关性。结果48例肝癌组织中Ki-67有程度不同的表达，阳性率为83．3％（40／45），在相应的癌旁组织中Ki-67无表达（P〈0．01）。在癌组织及癌旁组织CD34标记的MVD分别为32．17±8．06、10．83±2．85，癌组织的MVD要高于癌旁组织（P〈0．01）。肝癌组织中年龄与Ki．67表达水平及MVD均呈负相关（r=-0．418，P：0．003；r=-0．443，P=0．002）。结论肝癌组织中Ki-67表达水平及MVD与患者年龄呈负相关，提示年轻的肝癌患者可能预后更差。Objective To investigate the correlation between patient＂ s age and expression of Ki-67 or microvessel density in primary hepatocellular carcinoma. Methods The expression level of Ki-67 and the microvessel density in the hepatocellular carcinoma tissues were detected by immunohistochemical method, and the correlation between age and expression of Ki-67 or microvessel density were analyzed. Results In 48 cases of hepatocellular carcinoma tissues, Ki-67 expressed to varying degrees, but the positive rate was 83.3 % （40/45）, and there was no expression in corresponding noncancerous tissues （P 〈 0.01）. Microvessel density marked by CD34 in cancer tissues and noncancerous tissues were 32.17±8.06 and 10.83 ±2.85 respectively. Microvessel density of cancer tissues was higher than noncancerous tissues （P 〈 0.01）. Both levels of Ki-67 expression and microvessel density in hepatocellular carcinoma were negatively correlated with the age （r = -0.418, P = 0.003 and r = -0.443, P = 0.002 respectively）. Conclusion Both levels of Ki-67 expression and microvessel density in hepatocellular carcinoma are negatively correlated with patient＇ s age, which may suggest worse prognosis for the younger patients.

关 键 词：癌 肝细胞 KI-67 微血管密度 相关性分析 

分 类 号：R735.7[医药卫生—肿瘤]