侵袭性垂体腺瘤相关抑癌基因研究进展  

Research Progress in Invasive Pituitary Adenomas Related Tumor Suppressor Gene

作　　者：胡业帅[1] 杨军[1] 马顺昌[1] 常永凯[1] 

机构地区：[1]首都医科大学附属复兴医院,北京100038

出　　处：《中国肿瘤》2014年第6期494-496,共3页China Cancer

基　　金：北京市教育委员会科技计划面上项目(KM201210025023);首都医科大学附属复兴医院青年科研基金项目(YQN201204)

摘　　要：侵袭性垂体腺瘤是一类特殊的垂体腺瘤,可向周围组织侵犯,危害性大,但发病机制未明。目前已证实垂体腺瘤是由单克隆发生的,可能由原始干细胞基因突变导致细胞增殖引起,即可能与抑癌基因的突变密切相关。因此,对侵袭性垂体腺瘤相关抑癌基因的研究至关重要,为在分子生物学层面研究垂体腺瘤侵袭性机制提供科学依据。Invasive pituitary adenomas are special pituitary adenomas and can create greater damage, but their pathogenesis is still unknown. It has been certified that pituitary adenomas are derived from monoclonal and are caused by gene mutation. Therefore,the research of invasive pituitary adenomas related tumor suppressor gene is of great significance. It could provide a new evidence to explore the molecular mechanism of invasive pituitary adenoma in the field of molecular biology.

关 键 词：垂体腺瘤 侵袭性 抑癌基因 基因表达 

分 类 号：R736.4[医药卫生—肿瘤]