安非他酮治疗抑郁障碍的疗效和安全性  

Efficacy and Safety of Bupropion in the treatment of depression

作　　者：蒋雷[1] 

机构地区：[1]泰安市精神卫生中心,山东泰安271021

出　　处：《泰山医学院学报》2014年第4期279-280,共2页Journal of Taishan Medical College

摘　　要：目的评价安非他酮治疗抑郁症的疗效和安全性。方法将60例符合CCMD-3诊断标准的抑郁症患者随机分为安非他酮组和丙米嗪组各30例,分别治疗6周。采用汉密尔顿抑郁量表(HAMD)评定疗效,采用副反应量表(TESS)评定药物的不良反应。结果两组治疗后HAMD评分均较治疗前有显著降低(P<0.05),治疗1、2、4、6周末两组间HAMD评分均无显著差异(P>0.05)。治疗第4、6周末,安非他酮组TESS评分低于丙米嗪组,差异有显著性(P<0.05)。结论安非他酮治疗抑郁症有效,且不良反应发生率低于丙米嗪。Objective：To evaluate the efficacy and safety of Bupropion in the treatment of depression. Methods 60 patients who met CCMD-3 were assigned randomly into the Bupropion group or the Imipramine group. The Bupropion group was treated with Burpropion,while the Imipramine group was treated with Imipramine for 6 weeks. Effects and side effects were evalued seperately with HAMD and TESS before and after the treatment. Results：The scores of HAMD decreased significant-ly in both group after the completion of treatment（P﹤0. 05）,while in each same period,the scores shew no significant difference between the two group（P﹥0. 05）. The scores of TESS in Bupropion group became significantly lower than in the Imipramine at the end of 4 and 6 week（P﹤0. 05）. Conclusion：Bupropion can improve the therapeutic effect significantly and less side effects than Imipramine.

关 键 词：安非他酮 丙米嗪 抑郁症 对照研究 

分 类 号：R749.4[医药卫生—神经病学与精神病学]