胃癌患者血清IL-17、IL-6和TGF-β1水平及其临床意义  

Serum IL-17, IL-6 and TGF-β1 levels in Patients with Gastric Cancer and their Clinical Significances

作　　者：周长宏[1] 马健[1] 王涛[1] 董全江[2] 孟欣颖[1] 

机构地区：[1]青岛市市立医院(东区)干保二科,山东青岛266071 [2]青岛市市立医院(东区)消化内科,山东青岛266071

出　　处：《现代生物医学进展》2014年第15期2882-2885,共4页Progress in Modern Biomedicine

摘　　要：目的：探讨胃癌患者外周血中白介素17（IL-17）、白介素6（IL-6）和转化生长因子-β1（TGF-β1）的表达水平及其临床意义。方法：选择2009年1月-2010年1月我院收治的50例胃癌患者（观察组）及同期50例健康对照者（对照组）为研究对象，采用ELISA法检测和比较其外周血中IL-17、1L-6和TGF-β1的水平，并分析胃癌患者外周血中IL-17、IL-6和TGF-β1水平与其临床病理特征之间的相关性。结果：观察组患者外周血中IL-17、IL-6和TGF-β1的水平分别为（8．51±2．68）pg／ml、（7．81±5．41）pg／ml和（1093．42±831．21）pg／ml，均明显高于健康对照组（P〈0．01）。胃癌患者的血清IL-17、TGF-β1的水平与其年龄、性别、临床分期、有无淋巴结转移、分化程度、肿瘤部位及大小均无明显相关性（P〉0．05）；而血清IL-6的水平与肿瘤的大小相关（P〈0．05），但与其他临床病理特征无关（P〉0．05）；血清IL-17水平与IL-6、TGF-β1的水平均无明显相关性（P〉0．05）。结论：血清IL-17、IL-6和TGF-β1水平的升高与胃癌的发生有关，但IL-6和TGF-β1可能不是血清中IL-17生成的诱导因子。Objective： To explore the expression level of serum interleukin （IL）-17, 1L-6 and transforming growth factor （TGF）-β1 in patient with gastric cancer and their clinical significances. Methods： Total 50 patients with gastric cancer （observation group） and 50 healthy controls （control group） were enrolled as subjects from January 2009 to January 2010. Levels of serum IL-17, IL-6 and TGF-β1 were detected and compared by enzyme linked immunosorbent assay （ELISA）, and relationship between levels of serum IL-17, IL-6 and TGF-β1 and the clinical pathological characteristics was also analyzed. Results： Compared with healthy controls, patients with gastric cancer showed higher levels of serum IL-17, IL-6 and TGF-β1, with the value of（8.51±2.68） pg/ml, （7.81± 5.41） pg/ml and （1093.42± 831.21） pg/ml respectively （P〈0.01）. The concentration of serum IL-17 and TGF-β1 had no significant differences between age, sex, tu- mor stage, histological differentiation, tumor location and tumor size （P〉0.05）, while serum IL-6 had positive relation with tumor size （P〈0.05）. There were no relations between expression of IL-17 and IL-6, TGF-β1. Conclusion： Increased expression of serum IL-17, IL-6 and TGF-β1 might be involved in the development of gastric cancer. IL-6 and TGF-β1 might not be the stimulating factors for in- ducing IL-17 generation in peripheral blood in gastric cancer.

关 键 词：白介素17 白介素6 转化生长因子-Β1 胃癌 临床意义 

分 类 号：R735.2[医药卫生—肿瘤]