海藻酸钠壳聚糖微球作为药物载体的研究进展  

Advances in Applications of Chitosan—Sodium Alginate Microsphere to Drug Carriers for Microparticulated Systems

作　　者：汪程[1] 汪令伟 史晓宇[1] 由茂端[1] 许剑扬[1] 王林[1] 

机构地区：[1]大连大学附属中山医院胸心外科,辽宁大连116001

出　　处：《现代生物医学进展》2014年第16期3174-3176,共3页Progress in Modern Biomedicine

基　　金：辽宁省自然科学基金项目(2011225013)

摘　　要：海藻酸钠壳聚糖微球是具有生物粘附性且能结合和传递大分子药物的天然高分子材料,且在生物医学领域具有广阔应用前景的药物载体。它具有生物黏附性、生物相容性、生物可降解性、对人体无毒性且能够结合和传递大分子药物的天然高分子材料。海藻酸钠壳聚糖微球作为载药微球具有提高药物的生物利用度、延长药物的作用时间等优点。国内外近些年已将其应用于药剂学领域,以及将其作为药物载体经微球化与药物结合形成给药系统的研究也在逐步开展并取得了较多成果。本文主要阐述海藻酸钠壳聚糖微球的主要生物特性、作用特点及其在医学领域中应用的研究进展,并对其应用前景进行探讨。Chitosan-sodium alginate microsphere with bioadhesive can combine and delivery of macromolecular drugs natural polymers. They have broad application prospects in the field of biomedical drug carders. Chitosan-sodium alginate microsphere are biocompatible, biodegradable, and produce no systemic toxicity on administration. Drug-loaded microspheres have the advantage of improving the bioavilability and extending the drugs action time. Out of our country, chitosan-sodium alginate has been applied on Pharmacy and the study of chitosan-sodium alginate to drug carders for microparticulated systems is develoing fleetly. This article focuses on the biological properties, the main biological characteristics of and its applications of research advance in the medical field of chitosan-sodium alginate, microspheres.

关 键 词：海藻酸钠 壳聚糖 微球 药物载体 

分 类 号：R914[医药卫生—药物化学] R284[医药卫生—药学]