90例多发性骨髓瘤患者校正血钙的临床分析  

Patients with multiple myeloma after correcting serum calcium: Clinical analysis of 90 cases

作　　者：何红华[1] 

机构地区：[1]广东医学院附属医院血液内科,广东湛江524001

出　　处：《中国现代医生》2014年第16期1-3,共3页China Modern Doctor

基　　金：广东省湛江市第二批非资助科技攻关计划项目(2012B01179)

摘　　要：目的对多发性骨髓瘤(MM)患者血钙水平校正前后的临床指标行分析比较。方法回顾性分析90例MM患者的血钙水平,结合血清白蛋白水平进行血钙校正。同时检测90例MM患者的血肌酐、尿酸、球蛋白水平,且对患者行全身骨X线检查。结果校正后低钙组病例数下降,高钙组例数增加;将X线下MM患者骨损害分轻、中、重度三组,校正后各组血钙浓度均较前增加,重度损害组尤为显著;高尿酸组及肌酐异常组校正后血钙浓度均增加。结论 MM患者经过血清白蛋白校正治疗后,高血钙的发生率明显增加。校正后的血钙高水平提示MM患者可能存在骨损害和肾功能损害。Objective To analyze the differences of serum creatinine, uric acid and globin in patients with multiple myeloma （MM） after corrected calcium level by serum albumin. Methods The retrospective analysis was used to evaluate the calcium levels of 90 patients with MM, which was corrected by serum albumin. The levels of serum creatinine, uric acid, and globin were examined. Meanwhile, the whole body bone scan by X-ray was used to evaluate the severity of bone lesion in patients with MM. Results After corrections of serum calcium level, the incidence of hypocalcaemia was decreased, whereas the incidence of hypercalcaemia was increased. Based on the severity of bone lesion, the pa- tients were subgrouped into three groups： mild, medium, and severe groups. The corrected calcium levels were signifi- candy elevated in all three groups, particularly in severe group. In addition, the levels of corrected calcium were sig- nificantly decreased in both high uric acid and high creatinine groups. Conclusion The incidence of hypercalcaemia was increased in patients with MM after corrected calcium levels by serum albumin. The corrected hyperealcaemia may indicate lesions of bone and kidney in patients with MM.

关 键 词：多发性骨髓瘤 校正血钙 

分 类 号：R733.3[医药卫生—肿瘤]