缺血性脑血管病患者用天新利博前后血小板聚集的变化  

Change of Platelet Aggregation in Ischemic Cerebrovascular Disease Before and After with Tabellae Ticlopidini Hydrochloridi

作　　者：翟艳苓[1] 王硕[1] 路阳[1] 刘复强[1] 钱筠[1] 郗兰华[1] 王京平[1] 

机构地区：[1]首都医科大学附属北京同仁医院,100730

出　　处：《伤残医学杂志》2000年第4期36-38,共3页Medical Journal of Trauma and Disability

摘　　要：目的：探讨天新利博对缺血性脑血管病（ＩＣＶＤ）患者血小板聚集影响的程度．方法：比浊法测定１２例ＩＣＶＤ患者治疗前后，用二种诱聚剂诱导的血小板聚集率．结果（ｘ±Ｓ）：ＩＣＶＤ组用药后第５天、第１０天ＡＤＰ诱导血小板聚集率（３２．８７％±１４．２％，４４．９９％±１２．３％）显著低于用药前（７１．８％±１１．１％）Ｐ＜０．０１；Ａｄｒ诱导的血小板聚集率与用药前比较则无显著性差异（Ｐ＞０．０５）．结论：天新利博对ＩＣＶＤ患者ＡＤＰ诱导的血小板聚集有明显抑制作用，对Ａｄｒ诱导的血小板聚集无影响．监测其血小板聚集率时，应选用ＡＤＰ作为诱聚剂．To investigate influence of the tabellae ticlopidini hydrochloridi (TTH) on the platelet aggregation of ischemic cerebrovascular disease (ICVD) patients. Methods: The rate of platelet aggregation was measured by turbidimetry of two species inductor induction in 12 patients with ICVD before and after treatment. Results: The ratio of platelet aggregation with ADP inductor at 5th, 10th day were respectively (32.87%±14.2%, 44.99%±12.3%) significantly lower than that before treatment (71.9%±11.1%, P<0.01). There was no significant difference between the ratio of platelet aggregation with Adr inductor and that before treatment (P>0.05). Conclusion: TTH could inhibit platelet aggregation by ADP induction but without effect on the rate of platelet aggregation by Adr induction. It might be better choice ADP with inductor to induce platelet during monitoring platelet aggregation in CIVD with treatment of TTH.

关 键 词：血小板聚集 缺血性脑血管病 天新利博 

分 类 号：R743.3[医药卫生—神经病学与精神病学]