IL-8及其受体药物与疾病的研究进展  

Research progress of IL-8 and its receptor drugs in diseases

作　　者：李瑶[1] 吕德官[1] 陈临溪[1] 

机构地区：[1]南华大学药物药理研究所,湖南衡阳421001

出　　处：《中国药理学通报》2014年第3期14-18,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 30901577;81270420);湖南省自然科学基金资助项目(No 12JJ8013)

摘　　要：白细胞介素-8(interleukin-8,IL-8),又称趋化因子CXCL8(CXCL8),是一种炎性趋化性因子。IL-8通过受体CXCR1和CXCR2产生多种生物学功能,包括促炎性细胞趋化、促血管生成、促有丝分裂和诱导细胞增殖等。研究发现IL-8与多种疾病尤其是肿瘤的发生发展关系密切,特异性地阻断IL-8及其受体CXCR1/2有望成为多种疾病的潜在治疗策略。interleukin-8 （IL-8）, also known as neutrophils fac- logical functions including promoting inflammation cell chelno- tor, is a proinflammatory cytokine. IL-8 plays a variety of bio- taxis, angiogenesis, mitosis and proliferation via its two G pro-tein-eoupled receptors, CXCR1 and CXCR2. Recent researches prove that IL-8 has a positive relationship with the development of diseases, especially tumor. Therefore, IL-8 and its receptors CXCR1/2 might be the potential therapy target of related diseases

关 键 词：白细胞介素-8 CXCR1 2 受体药物 血管生成 肿瘤 细胞增殖 

分 类 号：R05[医药卫生] R392