细胞因子在莱姆病中作用的研究进展  

Research advancement in action of cytokines in Lyme disease

作　　者：李覃[1] 邢杰[1] 王增田[2] 

机构地区：[1]武警后勤学院病原生物与免疫学教研室,天津300309 [2]武警后勤学院临床医学系,天津300309

出　　处：《中国药理学通报》2014年第3期26-29,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81202843);天津市应用基础与前沿技术研究计划重点项目(No 14JCZDJC;11JCYBJC14600);中国博士后科学基金特别资助资助项目(No 201104796);中国博士后科学基金面上项目(No20090461498)

摘　　要：莱姆病是一种以硬蜱作为传播媒介、由伯氏疏螺旋体感染所致的人兽共患传染病,临床表现多样,严重影响人类健康和生活质量。有关细胞因子在莱姆病发生发展中的作用尚未完全阐明,但国内外已经取得一系列研究进展。明确不同类型细胞因子在莱姆病中的作用不仅有利于揭示莱姆病发生发展的具体分子机制,还将大大促进细胞因子在莱姆病预防、诊断和药物治疗中的应用。现就细胞因子与莱姆病关系的研究作一综述。Lyme disease is a kind of natural loci disease, trans- mitted by the ticks and caused by Borrelia burgdorferi, which could cause multi-system damage clinically, and affect health and life quality of patients. However,the pathogenic mechanism d Lyme disease has not been clarified, although much progress has been made. This study on the action of eytokines in Lyme disease is intent on summarizing the researches on the relation- ship between cytokines and Lyme disease, which could not only illuminate the molecular mechanism of Lyme disease, but also promote its application for prevention, diagnosis and treatment.

关 键 词：莱姆病 伯氏疏螺旋体 细胞因子 炎症 靶点 治疗 

分 类 号：R05[医药卫生] R392.11