补阳还五汤和腰交感神经节切除对大鼠坐骨神经损伤的影响  

Effect of Bu Yang Huan Wu Decoction(补阳还五汤) Combined with Lumbar Sympathetic Ganglionectomy on Recovery of Sciatic Nerve

作　　者：刘青龙 秦振龙[2] 王绣伯[3] 

机构地区：[1]河北省唐山市中医医院外科,唐山063000 [2]北京中医药大学附属医院东方医院麻醉科,北京100078 [3]中国航天科技集团公司第五研究院502研究所第五研究院门诊部内科,北京100190

出　　处：《中国中西医结合外科杂志》2014年第1期50-53,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：河北省中医药管理局科研计划项目(2012145)

摘　　要：目的:探讨补阳还五汤和腰交感神经节切除对大鼠坐骨神经损伤的影响。方法:60只SD大鼠损伤左侧坐骨神经,随机分为2组,对照组钳夹并切除腰交感神经节(LSG),实验组在钳夹并切除腰交感神经节后加用补阳还五汤口服及药浴治疗。观察对照组和实验组大鼠左足皮肤温度、坐骨神经功能指数(SFI)和坐骨神经传导速度(SNCV)的差异。结果:实验开始后1、2周实验组皮肤温度较对照组有明显升高(P<0.01)。实验组的坐骨神经功能指数2、4、6周恢复均快于对照组(P<0.01)。分别测实验组、对照组的坐骨神经传导速度。实验组2、4、6周坐骨神经传导速度恢复快于对照组(P<0.01)。结论:补阳还五汤口服加药浴并切除腰交感神经节,对大鼠周围神经损伤后再生有明显的促进作用。Objective To investigate the effect of Bu Yang Huan Wu decoction （补阳还五汤） and LumbarSympathetic Ganglionectomy （LSG） on recovery of sciatic nerve. Methods Sixty Sprague Dawley rats with leftsympathectic ganglion injury were divided into two groups. The rats in control group received LSG only whilethose in the experimental group also took oral administration and medicine bath of Bu Yang Huan Wu decoction（补阳还五汤） as well as LSG. The skin temperature of their left feet, the sciatic nerve function index （SFI） aswell as the sciatic nerve conduction velocity （SNCV） were studied before and after injury. Results The skin tem-perature of their left feet in experiment group was higher than that in control group （P 〈 0.05）. The recovery ofSFT in experimental group was significantly better than that in control group （P 〈 0.01） at 2,4,6 weeks followingthe experiment. SNCV in the experimental group was significantly faster than that in control group （P 〈 0.01） af-ter Lumbar Sympathetic Ganglionectomy therapy for 2, 4 ,6 weeks. Conclusion Oral administration and medi-cine bath of BuYangHuanWu decoction and LSG is beneficial for injured peripheral nerve.

关 键 词：大鼠 坐骨神经 腰交感神经节切除 神经再生 补阳还五汤 

分 类 号：Q95-33[生物学—动物学] R745.42[医药卫生—神经病学与精神病学]