叶酸的合成  

Synthesis of Folic Acid

作　　者：陈文华[1] 

机构地区：[1]常州工程职业技术学院制药与生物工程技术系,江苏常州213164

出　　处：《中国医药工业杂志》2014年第6期511-512,共2页Chinese Journal of Pharmaceuticals

摘　　要：用1,1,3-三氯丙酮、N-（4-氨基苯甲酰）-L-谷氨酸和2,4,5-三氨基-6-羟基嘧啶硫酸盐反应制得叶酸粗品,再经酸析、碱精制得纯品.制备叶酸粗品所得母液经减压蒸馏处理可得含1,1,3-三氯丙酮的水溶液,能循环套用10次以上,平均收率65.2％,含量97.8％～98.6％.Folic acid was synthesized by reaction from 1,1,3-trichloropropan-2-one,N-（4-aminobenzoyl）-L-glutamic acid and 2,4,5-triamino-6-hydroxypyrimidine sulfate to afford the crude product,followed by acid precipitation and alkali refining.The mother liquor obtained in the preparation of the crude folic acid was vacuum distillated to afford 1,1,3-trichloropropan-2-one solution,and the recovered solution could be recycled and used for more than 10 times with the average yield of 65.2％ and purities of 97.8％-98.6％.

关 键 词：叶酸 贫血 营养剂 合成 

分 类 号：R977.29[医药卫生—药品]