端粒酶在宫颈癌及癌前病变活检标本中的表达及意义  

Telomerase activity in cervical cancer and prelignant lesions.

作　　者：许争峰[1] 胡娅莉[1] 王迅美[1] 戴鲁琴[1] 韩克[1] 束泽宝[1] 

机构地区：[1]南京大学医学院附属鼓楼医院妇产科,210088

出　　处：《中国优生与遗传杂志》2000年第6期24-24,39,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的 :探讨端粒酶在宫颈活检组织中的表达及意义。方法 :采用端粒重复序列扩增 酶标法 (TRAP ELISA)测定了 33例宫颈活检标本中端粒酶活性 ,其中宫颈癌 2 5例 (包括 2例原位癌 ) ,宫颈不典型增生 8例。结果 :宫颈癌端粒酶阳性检出率为 92 .0 % ,不典型增生阳性检出率为 2 5 .0 %。结论 :宫颈活检组织端粒酶检测 ,可用于宫颈癌的早期诊断 ;对有端粒酶活性表达的病例进行监测 ,可能有助于揭示宫颈癌的发生发展过程 ,宫颈上皮癌变的预测。To investigate the role of telomerase activity in cervical cancer and prelignant lesions.Methods:Using PCR-ELISA assay,we examined telomerae activity in 25 specimens of cervical cancer and 8 specimens of cervical atypical hyperphasia tissue.Results:23 of 25(92.0%) cervical cancer specimens and 2 of 8 (25.0%) cervical atypical hyperplasia tissue were positive telomerase activity.Conclusion:Detection of telomerase activity may serve as a tool for diagnosis and prognosis of cervical neoplasias.The expression of telomerase may play a crucial role in the process of cervical tumor genesis.

关 键 词：宫颈癌 不典型增生 端粒酶 癌前病变 

分 类 号：R737.33[医药卫生—肿瘤]