急性脑水肿时血浆和脑脊液β-内啡肽的变化及其意义  

Changes of β-endorphin in both of plasma and CSF and its significance in children with acute encephaledema following infection of central nervous system

作　　者：李光乾[1] 胡鸿文[1] 郑美琴[1] 张雅丽[1] 林忠东[1] 叶秀云[1] 

机构地区：[1]温州医学院育英儿童医院,325027

出　　处：《临床儿科杂志》2001年第1期23-25,共3页Journal of Clinical Pediatrics

基　　金：浙江省教委科研基金立项课题(编号:97171)

摘　　要：为探讨β-内啡肽(β-EP)在急性脑水肿发病中的作用,采用放射免疫法检测了69例中枢神经系统感染患儿(脑水肿组39例,无脑水肿组30例)和19例对照组小儿的血浆和脑脊液(CSF)中β-EP含量。结果显示:脑水肿组、无脑水肿组和对照组血浆β-EP含量分别为50.74ng/L±26.60ng/L、32.78ng/L±21.20ng/L和14.83ng/L±6.55ng/L,三组CSF中β-EP含量分别为62.72ng/L±39.23ng/L、34.13ng/L±30.26ng/L和9.77ng/L±6.33ng/L;脑水肿组血浆和CSF中β-EP均显著高于其他两组(P<0.01)。结果表明,β-EP在脑水肿的发生发展中起着重要作用。To explore the role of β-endorphin (β-EP) in the pathogenesis of the acute encephaledema, the levels of β-EP in both of plasma and CSF were determined by radioimmunoassay in 69 children with infection of central nervous system consisting of 39 cases with encephaledema and 30 cases without encephaledema > respectively. Another 19 cases without intracra-nial infection were as the control group. The results showed that the levels of plasma and CSF β-EP in the encephaledema group (50.74 ng/L ± 26. 60ng/L, 62. 72ng/L ± 39. 23ng/L) were significantly higher than those in without encephaledema group (32. 78 ng/L±21. 2ng/L,34. 13ng/L±30. 26ng/L)and the normal group (14. 83ng/L±6. 55ng/L,9. 77ng/L±6. 33ng/ L), respectively (P<0. 01). It is concluded that β-EP plays an important role in the occurrence and development of encephaledema in children with the infection of central nervous system.

关 键 词：急性脑水肿 血浆 脑脊液 Β-内啡肽 放射免疫测定 

分 类 号：R748[医药卫生—神经病学与精神病学]