菠萝叶酚对小鼠急性糖脂负荷吸收及其小肠脂肪酶活性的影响  

Effect of Phenols of Pineapple Leave on Lipid and Glucose Absorption and Intestinal Lipase Activity after Acute Consumption of Lipid and Glucose

作　　者：严孝金[1] 柴玉爽[1] 袁梽漪[1] 卢希[1] 雷帆[1] 邢东明[1] 杜力军[1] 

机构地区：[1]清华大学蛋白质科学教育部重点实验室/生命科学学院医学院药物药理实验室,北京100084

出　　处：《世界科学技术-中医药现代化》2014年第4期796-800,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家创新药物重大专项(2012ZX09103-201-041):糖脂代谢新药BLP的研究;负责人:邢东明

摘　　要：目的:研究表明从菠萝叶中制备的总酚类成分具有抗氧化和调血脂作用。由于其灌胃后吸收较快,血中5 min即达峰值,因此本文通过急性糖脂负荷实验观察菠萝叶酚对糖脂吸收的影响。方法:利用小鼠单次灌胃建立糖脂负荷模型,观察给药后不同时间对餐后血糖、血脂和小肠脂肪酶的变化。结果:菠萝叶酚在一定程度上能够抑制甘油三酯和葡萄糖的吸收。在给药30 min后未见到明显的作用,但此时正常小鼠小肠脂肪酶活性受到明显抑制,并且对高脂所致小肠脂肪酶活性下降有一定的解抑制作用。结论:提示菠萝叶酚的抑制脂类吸收可能与脂肪酶活性有关;其对于餐后高糖高脂吸收的有一定调控作用。This article was aimed to study the antioxidant and antihyperlipidemic effect of total phenolic composition prepared from pineapple （A nanas comosus L.） leave. It had a rapid absorption after intragastric administration and the principle ingredient, p-coumaric acid, reached the peak concentration after 5 minutes of administration. The mice model with single intragastric administration of lipid and glucose were used in the observation of changes on postprandial glucose, lipid and intestinal lipase at different time points after drug administration. The results showed that phenols of pineapple leave can inhibit triglyceride and glucose absorption in certain extent. No significant effect was observed on inhibition at 30 minutes after the phenol administration. However, the intestinal lipase activity was obviously inhibited in normal mice and the intestinal lipase activity decline caused by acute lipid consumption can be reversed. It was concluded that the phenols pineapple leave may inhibit the absorption of lipids with correlation to lipase activity. It had certain regulation effect on the high postprandial glucose and fat absorption.

关 键 词：菠萝叶酚 高血脂 高血糖 脂肪酶 

分 类 号：R285.5[医药卫生—中药学]