幽门螺杆菌感染与慢性胰腺炎的相关性分析  

Correlation analysis of Helicobacter pylori infections and chronic pancreatitis

作　　者：俞婷[1] 卢芩[1] 曹大中[1] 俞谦[1] 欧希龙[1] 王智[1] 

机构地区：[1]东南大学附属中大医院消化内科,江苏南京210009

出　　处：《中华医院感染学杂志》2014年第12期2985-2986,2997,共3页Chinese Journal of Nosocomiology

基　　金：江苏省科学技术厅基金资助项目(BS2006046)

摘　　要：目的调查分析幽门螺杆菌(Hp)与慢性胰腺炎(CP)的相关性,为临床预防治疗提供借鉴参考。方法将2011年12月-2013年2月收治的67例CP患者作为研究组,选择同期体检的40名健康者作为对照组,对比两组患者导致CP的危险因素,再对经单因素分析筛选出有统计学意义的危险因素,行logistic多因素回归分析,判断更具有独立作用的高危因素,采用SPSS13.0软件对数据进行统计分析。结果观察组67例患者中Hp感染33例,感染率为49.3%,对照组40例患者中Hp感染9例,感染率为22.5%;高血脂症、肝胆性疾病史、自身免疫病史及Hp感染与发生CP呈显著相关性;自身免疫疾病史(β=1.169,OR=1.994)、高血脂症(β=1.402,OR=3.276)、肝胆性疾病史(β=1.398,OR=2.681)及Hp感染(β=1.226,OR=1.337)会增加发生CP的风险,是更具独立的高危因素。结论 Hp感染会显著增加慢性胰腺炎的发病率,是慢性胰腺炎发生的高危因素,预防治疗Hp感染对于预防慢性胰腺炎具有重要意义。OBJECTIVE To investigate the correlation between Helicobacter pylor（Hp） and chronic pancreatitis （CP） so as to provide reference for clinical prevention and treatment .METHODS A total of 67 cases of CP patients treated in the hospital from Dec 2011 to Feb 2013 were included into the study group ,and 40 people examined to be healthy at the same time were included into control group ;the risk factors causing CP to the subjects of the two groups were compared , and the risk factors screened out through single factor analysis with statistically significance were analyzed by logistic multi-factor analysis method to determine the risk factors owning independent functions ;SPSS 13 .0 software was adopted for statistical analysis of data .RESULTS Totally ,33 of the 67 cases of patients in observation group suffered Hp ,with the infection rate of 49 .3% ;9 of the 40 cases of patients in control group suffered Hp ,with the infection rate of 22 .5% ;hyperlipidemia ,hepatic and gall disease history , autoimmunity disease history and Hp infection were significantly related with occurrence of CP ;autoimmunity disease history （β=1 .169 ,OR=1 .994） ,hyperlipidemia （β=1 .402 ,OR=3 .276） ,hepatic and gall disease history （β=1 .398 ,OR=2 .681） and Hp infection （β=1 .226 ,OR=1 .337） could increase the risk of CP ,and were risk factors owning more independent function .CONCLUSIONS HP infection can significantly increase the incidence of CP and is the risk factor causing CP ,therefore ,it is of great importance for prevention and treatment of Hp infection to preventing CP .

关 键 词：幽门螺杆菌 感染 慢性胰腺炎 危险因素 相关性分析 

分 类 号：R576[医药卫生—消化系统]